抗体药物筛选技术的研究进展  

Research Progress of Antibody Drug Screening Technology

作　　者：纪思佳 张小雪 翟丽丽 董静 李岩异 常亮[1] JI Sijia;ZHANG Xiaoxue;ZHAI Lili;DONG Jing;LI Yanyi;CHANG Liang(State Key Laboratory of Antibody Research&Development,Hebei Engineering Research Center of Antibody Medicine,North China Pharmaceutical Group Corporation New Drug Research and Development Co.,Ltd.,Shijiazhuang 052160,China;NCPC Genetech Biotechnology Co.,Ltd.,Shijiazhuang 050035,China)

机构地区：[1]华北制药集团新药研究开发有限责任公司,抗体药物研制国家重点实验室,抗体药物河北省工程研究中心,石家庄052160 [2]华北制药金坦生物技术股份有限公司,石家庄050035

出　　处：《生物技术进展》2025年第1期43-49,共7页Current Biotechnology

基　　金：河北省重点研发计划项目(22372401D)。

摘　　要：抗体药物经历了多克隆抗体、单克隆抗体及基因工程抗体三个阶段,随着人类对抗体药物的不断深入研究,出现了多克隆抗体技术、杂交瘤抗体技术、抗体文库展示技术以及转基因小鼠技术等多种抗体筛选技术。抗体药物具有非常大的发展前景,针对各种抗体药物筛选技术的特点进行整理归纳,并讨论了抗体药物研发面临的挑战,以期为后续抗体技术的发展提供参考。Antibody drugs have gone through three stages:polyclonal antibody,monoclonal antibody and genetically engineered antibody.With the continuous deepening of human research on antibody drugs,a variety of antibody screening technologies have emerged,such as polyclonal antibody technology,hybridoma antibody technology,antibody library display technology and trans⁃genic mouse technology.Antibody drugs have a very large development prospect.The article summarized the characteristics of various antibody drug screening technologies,and discussed the challenges faced by antibody drug research and development,in order to provide reference for the subsequent development of antibody technology.

关 键 词：抗体文库展示技术 转基因小鼠技术 单个B细胞抗体技术 人工智能 

分 类 号：Q511[生物学—生物化学] R979.1[医药卫生—药品]