2018-2022年湖北省肺结核合并糖尿病患者特征分析  

Epidemiological characteristics of pulmonary tuberculosis patients complicated with diabetes mellitus in Hubei 2018-2022

作　　者：王凡 卢星星[1] 张玉[1] 张梦娴 夏雨荷 舒智雄 周丽平[1] WANG Fan;LU Xingxing;ZHANG Yu;ZHANG Mengxian;XIA Yuhe;SHU Zhixiong;ZHOU Liping(Hubei Provincial Center for Disease Control and Prevention,Wuhan,Hubei 430079,China)

机构地区：[1]湖北省疾病预防控制中心,湖北武汉430079

出　　处：《中国预防医学杂志》2024年第12期1574-1579,共6页Chinese Preventive Medicine

摘　　要：目的监测湖北省2018-2022年肺结核合并糖尿病(pulmonary tuberculosis and diabetes mellitus,PTB-DM)患者的特点,为其防治提供科学依据。方法通过“结核病管理信息系统”收集湖北省2018年1月1日-2022年12月31日登记的肺结核患者资料,采用Stata 15.0统计软件进行描述性分析,Joinpoint软件进行年登记率趋势性分析。结果2018-2022年湖北省共登记PTB-DM患者8787例,占肺结核患者5.47%,年均登记率为2.99/10万(8787/29351.30万),2018-2022年年登记率逐年上升,差异有统计学意义(APC=16.60%,95%CI:6.30~27.90,t=5.284,P=0.013);各地市(州)PTBDM患者年均登记率差异较大,十堰市、鄂州市、荆门市、恩施土家族苗族自治州年登记率均呈快速上升趋势,差异有统计学意义(APC=20.10%、57.60%、45.00%、16.40%,P<0.05)。PTB组与PTBDM组患者年龄、性别、职业比较,差异有统计学意义(χ^(2)=2440.963、255.523、1235.093,P<0.01)。PTB-DM组患者病原学阳性构成比、转诊构成比、复治率、耐药率和确诊延迟率均高于PTB组,差异有统计学意义(χ^(2)=1170.48、402.534、197.417、5.905、182.211,P<0.05);就诊延迟率、固定剂量复合制剂使用率、成功治疗率均低于PTB组,差异有统计学意义(χ^(2)=22.757、401.200、396.958,P<0.01)。结论2018—2022年湖北省PTB-DM患者年登记率上升明显,传染性强,治疗转归不佳,应进一步加强肺结核和糖尿病人群双向筛查与发现,落实PTB-DM患者早期诊断和规范治疗,完善不同地区、不同人群中PTB-DM患者防治策略。Objective To monitor the characteristics of pulmonary tuberculosis patients complicated with diabetes mellitus(PTB-DM)in Hubei Province from 2018 to 2022,providing scientific evidence for the prevention and treatment.Methods Data on patients with pulmonary tuberculosis(PTB)registered in Hubei Province from January 1,2018,to December 31,2022,were collected through the tuberculosis information management system.Stata 15.O was used for descriptive analysis,and Joinpoint software was used to analyze the trend of annual registration rate.Results A total of 8787 patients with PTB-DM were registered in Hubei Province from 2018 to 2022,accounting for 5.47%of all PTB patients,with an average annual registration rates of 2.99/100000(8787/293513000).The annual registration rate showed a statistically significant increasing trend from 2018 to 2022(APC=16.60%,95%CI:6.30-27.90,t=5.284,P=0.013).There were significant differences in the annual registration rates of PTB-DM patients among different cities(states),with Shiyan,Ezhou,Jingmen,Enshi Tujia,and Miao Autonomous Prefecture showing rapid increases(APC=20.10%,57.60%,45.00%,16.40%,P<O.05).Comparisons of age,gender,and occupation between PTB and PTB-DM groups revealed significant differences(x?=2440.963,255.523,1235.093,P<0.01).The PTB-DM group exhibited higher proportions of positive microbiological tests,referral rates,relapse rates,drug resistance rates,and diagnostic delay rates compared to the PTB-DM group,with significant diferences(2=1170.48,402.534,197.417,5.905,182.211,P<0.05).Conversely,the PTB-DM group had lower rates of consultation delays,fixed-dose combination therapy usage,and successful treatment outcomes(2=22.757,401.200,396.958,P<0.01).ConclusionssFrom 2018 to 2022,the registration rate of PTB-DM patients in Hubei Province increased significantly,indicating a strong infectious potential and poor treatment outcomes.There is an urgent need to enhance bidirectional screening and detection of tuberculosis and diabetes populations,ensure early diagnosis and standa

关 键 词：肺结核 糖尿病 共病 流行病学 

分 类 号：R521[医药卫生—内科学] R587.1[医药卫生—临床医学]