Noninvasive high-resolution deep-brain photoacoustic imaging with a negatively focused fiber-laser ultrasound transducer  

作　　者：HEXIANG XU ZITAO CHEN YUHAN WU CHENGTIAN HOU JUN MA BAI-OU GUAN 

机构地区：[1]Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications,Institute of Photonics Technology,Jinan University,Guangzhou 510632,China [2]College of Physics&Optoelectronic Engineering,Jinan University,Guangzhou 510632,China

出　　处：《Photonics Research》2024年第12期2996-3005,共10页光子学研究(英文版)

基　　金：National Natural Science Foundation of China(62275106,62135006);Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2019BT02X105);Natural Science Foundation of Guangdong Province(2022A1515010105,2023A1515011415)。

摘　　要：Noninvasive high-resolution deep-brain imaging is essential to fundamental cognitive process study and neuroprotective drugs development.Although optical microscopes can resolve fine biological structures with good contrast without exposure to ionizing radiation or a strong magnetic field,the optical scattering limits the penetration depth and hinders its capability for deep-brain imaging.Here,in vivo high-resolution imaging of the whole mouse brain is demonstrated by using a photoacoustic computed tomography system with a negatively focused fiber-laser ultrasound transducer.By leveraging the high flexibility and low bending loss of the optical fiber,a rationally designed negatively focused fiber laser cavity exhibits a low detection limit down to 5.4 Pa and a broad view angle of∼120 deg,enabling mouse brain imaging with a penetration larger than 7 mm and a nearly isotropic spatial resolution of∼130μm.In addition,the negative curvature of the fiber laser reduces the working distance,which facilitates the development of a compact and portable linear scanning imaging system.In vivo imaging of a mouse model with intracerebral hemorrhage is also showcased to demonstrate its capability for potential biomedical and clinical applications.With high spatial resolution and large tissue penetration,the system may provide a noninvasive,user-friendly,and high-performance imaging solution for biomedical research and preclinical/clinical diagnosis.

关 键 词：FIBER scattering resolution 

分 类 号：TB552[理学—物理] TP391.41[理学—声学]