人参皂苷CK的规模化制备及生物活性研究进展  

Research progress on large-scale preparation and biological activity of ginsenoside CK

作　　者：曹静怡 曹园 张佳汝 周杨佳兰 郭珍妮 邵娟娟[1] CAO Jingyi;CAO Yuan;ZHANG Jiaru;ZHOU Yangjialan;GUO Zhenni;SHAO Juanjuan(College of Science and Technology,Agricultural University of Hebei,Cangzhou 061000,China)

机构地区：[1]河北农业大学理工系,河北沧州061000

出　　处：《食品与发酵工业》2025年第5期371-379,共9页Food and Fermentation Industries

基　　金：河北农业大学2024年大学生创新创业训练计划基金项目(2024005)。

摘　　要：人参是一种名贵的中药材,稀有人参皂苷是人参最有效的功能成分,通过生物转化方法制备稀有人参皂苷已成为当下研究热点。人参皂苷Compound K(人参皂苷CK)具有抗肿瘤、抗炎症、延缓皮肤衰老、抗糖尿病及其并发症、抗抑郁、抗骨质疏松症等生物活性。该文结合国内外相关研究,系统综述了适合大规模制备人参皂苷CK的方法及其生物活性,以期为人参皂苷CK的大批量生产及进一步探索其药理机制提供参考意见。Ginseng is a valuable Chinese herbal medicine,and rare ginsenosides are the most effective functional components in ginseng.The preparation of rare ginsenosides by biotransformation has become a research hotspot.Ginsenoside compound K(ginsenoside CK)has the capacity to be anti-tumor,anti-inflammatory,anti-aging skin,anti-diabetes,anti-depression,and anti-osteoporosis agents,while maintains other beneficial biological properties.In this paper,the methods suitable for large-scale preparation of ginsenoside CK and its biological activity were systematically reviewed to provide reference for the massive production of ginsenoside CK and further exploration of its pharmacological mechanism.

关 键 词：人参皂苷CK 人参 生物转化 化学法 生物活性 

分 类 号：TQ461[化学工程—制药化工]