造血干细胞移植术后长期认知功能障碍的影响因素及其与睡眠和复发恐惧的相关性  

Influencing factors of long-term cognitive impairment after hematopoietic stem cell transplantation surgery and their correlation with sleep and fear of recurrence

作　　者：王欢欢[1] 赵荣 韩春霞[1] 庞楠楠[3] WANG Huanhuan;ZHAO Rong;HAN Chunxia;PANG Nannan(Department of Hematology,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,Xinjiang,China;Department of Critical Care Medicine,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,Xinjiang,China;Hematology Center Laboratory,the First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,Xinjiang,China)

机构地区：[1]新疆医科大学第一附属医院血液科,新疆乌鲁木齐830011 [2]新疆医科大学第一附属医院重症医学科,新疆乌鲁木齐830011 [3]新疆医科大学第一附属医院血液病中心实验室,新疆乌鲁木齐830011

出　　处：《中南医学科学杂志》2025年第1期45-48,共4页Medical Science Journal of Central South China

基　　金：国家自然科学基金项目(81960039)。

摘　　要：目的分析造血干细胞移植(HSCT)术后患者长期认知功能障碍的影响因素及其与睡眠和复发恐惧的相关性。方法观察418例HSCT术后患者长期认知功能障碍的发生情况。根据认知功能障碍严重程度分为轻度障碍组、中度障碍组和重度障碍组。采用癌症治疗功能评估-认知功能量表(FACT-Cog)、癌症治疗功能评诂-骨髓移植量表(FACT-BMT)、匹茨堡睡眠质量指数(PSQI)、恐惧疾病进展简化量表(FoP-Q-SF)评估各组认知功能、生活质量、睡眠质量和复发恐惧情况。Logistic回归分析HSCT术后长期认知功能障碍严重程度的影响因素。采用Spearman相关分析PSQI、FoP-Q-SF与FACT-Cog评分的相关性。结果HSCT术后长期认知功能障碍发生92例(22.0%),其中轻度30例(32.6%),中度40例(43.5%),重度22例(23.9%)。随着认知功能障碍程度加重,FACT-BMT评分中各维度和总分逐渐降低(P<0.05),PSQI、FoP-Q-SF评分逐渐升高(P<0.05)。PSQI、FoP-Q-SF评分是HSCT术后长期认知功能障碍严重程度的影响因素。PSQI、FoP-Q-SF评分与FACT-Cog评分呈正相关(P<0.05)。结论HSCT术后长期认知功能障碍发生率高;PSQI、FoP-Q-SF评分是HSCT术后长期认知功能障碍严重程度的影响因素,且与HSCT术后患者长期认知功能障碍发生呈正相关。Aim To analyze the influencing factors of long-term cognitive impairment in patients after hematopoietic stem cell transplantation(HSCT)and their correlation with sleep and fear of recurrence.Methods The occurrence of long-term cognitive impairment in 418 patients after HSCT surgery were monitored.The patients were divided into mild impairment group,moderate impairment group,and severe impairment group based on the severity of cognitive impairment.The cognitive function,quality of life,sleep quality,and fear of recurrence in each group were evaluated by using the functional assessment of cancer therapy-cognitive function(FACT-Cog),the functional assessment of cancer therapy-bone marrow transplant(FACT-BMT),Pittsburgh sleep quality index(PSQI),and the fear of progression questionnaire-short form(FoP-Q-SF).The influencing factors of long-term cognitive impairment severity after HSCT surgery were analyzed by using Logistic regression.The correlation between PSQI,FoP-Q-SF,and FACT-Cog scores were examined by using Spearman correlation analysis.Results 92 cases(22.0%)experienced long-term cognitive impairment after HSCT surgery,of which 30 cases(32.6%)were mild,40 cases(43.5%)were moderate,and 22 cases(23.9%)were severe.As cognitive impairment worsened,the dimensions and total score of FACT-BMT score were decreased gradually(P<0.05),while the PSQI and FoP-Q-SF scores were increased(P<0.05).PSQI and FoP-Q-SF scores were influencing factors for the severity of long-term cognitive impairment after HSCT surgery.PSQI score,FoP-Q-SF score,and FACT-Cog score were positively correlated(P<0.05).Conclusion The incidence of long-term cognitive impairment after HSCT surgery is high.PSQI,FoP-Q-SF score are influencing factors for the severity of long-term cognitive impairment after HSCT surgery,and are positively correlated with long-term cognitive impairment in HSCT patients.

关 键 词：造血干细胞移植 认知功能障碍 睡眠质量 复发恐惧 影响因素 

分 类 号：R55[医药卫生—血液循环系统疾病]