曲马多联合普瑞巴林对带状疱疹后神经痛疗效及血清β-EP、NK-1的影响  

The effect of tramadol combined with pregabalin on postherpetic neuralgia and the changes of serumβ-EP and NK-1

作　　者：刘佩 胡晓莉 朱敏[1] 徐峰[1] 彭为 LIU Pei;HU Xiaoli;ZHU Min;XU Feng;PENG Wei(Department of Pain Treatment,Xuzhou First People s Hospital,Xuzhou 221000,Jiangsu,China;Department of Pharmacy,Nanjing Yuhua Hospital,Xuzhou 210012,Jiangsu,China)

机构地区：[1]徐州市第一人民医院疼痛科,江苏徐州221000 [2]南京市雨花医院药剂科,江苏南京210012

出　　处：《中南医学科学杂志》2025年第1期70-73,共4页Medical Science Journal of Central South China

基　　金：江苏省科技基础研究计划自然科学基金(BK20220661)。

摘　　要：目的观察曲马多联合普瑞巴林对带状疱疹后神经痛(PHN)疗效及血清β-内啡肽(β-EP)、神经激肽-1(NK-1)的影响。方法选取PHN患者100例,随机均分为对照组(普瑞巴林)和观察组(曲马多联合普瑞巴林)。比较两组疗效、疼痛、睡眠、生活质量、不良反应情况,以及血清β-EP、NK-1、白细胞介素(IL)-6、IL-1β水平。结果观察组治疗总有效率高于对照组(P<0.05)。两组治疗期间不良反应发生率比较差异无显著性(P>0.05)。与治疗前比较,治疗后两组视觉模拟评分、匹兹堡睡眠质量指数评分、IL-1β、IL-6、NK-1水平降低,皮肤病学生活质量量表评分、β-EP水平升高,且治疗后观察组较对照组变化更为显著(P<0.05)。结论曲马多联合普瑞巴林治疗PHN疗效佳,可改善血清β-EP、NK-1水平,值得临床推广。Aim To observe the therapeutic effects of tramadol combined with pregabalin on postherpetic neuralgia(PHN)and the influence of treatment on serumβ-endorphin(β-EP)and neurokinin-1(NK-1).Methods 100 patients with PHN were selected and randomly divided into a control group(pregabalin)and an observation group(tramadol combined with pregabalin).The efficacy,pain,sleep,quality of life,adverse reactions,as well as serum levels ofβ-EP,NK-1,interleukin(IL)-6,and IL-1βbetween two groups were compared.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two treatment groups(P>0.05).Compared with before treatment,the visual analog score,Pittsburgh sleep quality index score,IL-1β,IL-6,and NK-1 levels decreased in both groups after treatment,while the dermatology quality of life scales andβ-EP levels increased,moreover,the changes in the observation group were more significant than those in the control group after treatment(P<0.05).Conclusion The combination of tramadol and pregabalin has a good therapeutic effect on PHN to improveβ-EP and NK-1 levels,and is worthy of clinical promotion.

关 键 词：曲马多 普瑞巴林 PHN Β-EP NK-1 带状疱疹后神经痛 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]