血清CGRP和趋化因子水平与支气管哮喘患者气道炎症及疾病进展的关系  

Association of serum CGRP and chemokine levels with airway inflammation and disease progression in patients with bronchial asthma

作　　者：陈翠仪 吴雷 陈锦暖 黄柳媚 李智 CHEN Cuiyi;WU Lei;CHEN Jinnuan;HUANG Liumei;LI Zhi(The Affiliated Dongguan Songshan Lake Central Hospital,Guangdong Medical University,Dongguan 523300,Guangdong,China;School of Public Health,Guangzhou Medical University,Guangzhou 510180,Guangdong,China)

机构地区：[1]广东医科大学附属东莞松山湖中心医院呼吸内科,广东东莞523320 [2]广州医科大学公共卫生学院,广东广州510180

出　　处：《中南医学科学杂志》2025年第1期74-77,共4页Medical Science Journal of Central South China

基　　金：广东省医学科学技术研究基金项目(A2020324)。

摘　　要：目的探讨支气管哮喘患者血清降钙素基因相关肽(CGRP)和趋化因子水平与气道炎症及疾病进展的关系。方法将支气管哮喘患者61例分为急性组(急性发作期患者37例)和慢性组(急性发作期患者37例)。比较两组患者一般资料和实验室检测结果,通过Logistic模型分析支气管哮喘急性发作的危险因素。结果急性组年龄、体质指数、血清CGRP和趋化因子水平、诱导痰炎症细胞类型指标和炎症相关细胞因子水平均高于慢性组(P<0.05)。Logistic分析结果显示,血清CGRP、CXCL13、MIP-1α、MCP-1水平、诱导痰IL-4、IL-9、嗜酸性粒细胞百分比均为支气管哮喘急性发作的危险因素(P<0.05)。ROC曲线分析结果显示,血清CGRP和趋化因子水平联合检测的支气管哮喘急性发作判断效能最佳。Pearson相关分析结果显示,支气管哮喘患者血清CGRP和MIP-1α水平均与诱导痰炎症细胞类型指标和炎症相关细胞因子水平呈正相关(P<0.05);血清CXCL13与诱导痰IL-6、IL-9、嗜酸性粒细胞百分比、中性粒细胞百分比均呈正相关(P<0.05);血清MCP-1水平与诱导痰IL-6、IL-13、中性粒细胞百分比均呈正相关(P<0.05)。结论支气管哮喘患者血清CGRP和趋化因子水平与其气道炎症及疾病进展均密切相关。Aim To investigate the association of serum calcitonin gene related peptide(CGRP)and chemokines levels with airway inflammation and disease progression in patients with bronchial asthma.Methods 61 patients diagnosed with bronchial asthma were selected as the acute group(37 patients with acute exacerbation)and the chronic group(24 patients with chronic duration).The general information and laboratory test results of two groups of patients were compared,and the risk factors for acute exacerbation of bronchial asthma were analyzed by Logistic model.Results The age,body mass index,serum CGRP and chemokine levels,induced sputum inflammatory cell type indicators,and inflammatory related cytokine levels in the acute group were higher than those in the chronic group(P<0.05).The results of Logistic analysis showed that serum CGRP,CXCL13,MIP-1α,MCP-1 levels,induced sputum IL-4,IL-9,and percentage of eosinophils,were all risk factors for acute exacerbation of bronchial asthma(P<0.05).The ROC curve analysis results showed that combined detection of serum CGRP and chemokine levels had the best diagnostic efficacy for acute exacerbation of bronchial asthma.The Pearson correlation analysis results showed that the serum CGRP and MIP-1αlevel in patients with bronchial asthma was positively correlated with induced sputum inflammatory cell type indicators and inflammation-related cytokine levels(P<0.05);Serum CXCL13 was positively correlated with induced sputum IL-6,IL-9,eosinophil percentage and neutrophil percentage(P<0.05);Serum MCP-1 level was positively correlated with induced sputum IL-6,IL-13 and neutrophil percentage(P<0.05).Conclusion Serum CGRP and chemokines levels in patients with bronchial asthma are closely related to airway inflammation and disease progression.

关 键 词：支气管哮喘 降钙素基因相关肽 趋化因子 气道炎症 疾病进展 

分 类 号：R562.25[医药卫生—呼吸系统]