心肌梗死患者血清SFRP5、S100A4表达与心肌损伤和左心室重构的关系  

Relationship between expression of SFRP5 and S100A4 and myocardial injury and left ventricular remodeling in patients with myocardial infarction

作　　者：朱伟 李蕊 ZHU Wei;LI Rui(Department of Clinical Laboratory,Yuncheng Central Hospital Affiliated to Shanxi Medical University,Yuncheng 044000,Shanxi,China)

机构地区：[1]山西医科大学附属运城市中心医院检验科,山西运城044000

出　　处：《中南医学科学杂志》2025年第1期89-91,共3页Medical Science Journal of Central South China

基　　金：山西省回国留学人员科研资助项目(2022-176)。

摘　　要：目的分析心肌梗死(MI)患者血清分泌型卷曲相关蛋白5(SFRP5)、S100钙结合蛋白A4(S100A4)表达与心肌损伤和左心室重构的关系。方法选择心肌梗死患者(MI组)、健康体检者(对照组)各80例。比较两组左心室重构指标[左室舒张末内径(LVEDD)、左室舒张末容积(LVEDV)、左室收缩末容积(LVESV)、左室射血分数(LVEF)]、血清SFRP5、S100A4、脂蛋白相关磷脂酶A2(Lp-PLA2)、氨基末端脑钠肽前体(NT-proBNP)水平。结果MI组LVESV、LVEDV、LVEDD高于对照组,LVEF低于对照组(P<0.05)。MI组Lp-PLA2、NT-proBNP、SFRP5和S100A4水平高于对照组(P<0.05)。SFRP5、S100A4与LVESV、LVEDV、LVEDD、Lp-PLA2、NT-proBNP呈正相关,与LVEF呈负相关(P<0.05)。结论心肌梗死患者血清SFRP5和S100A4异常表达,且与心肌损伤和左心室重构关系密切。Aim To analyze the relationship between serum secreted frizzled related protein 5(SFRP5),S100 calbindin A4(S100A4)expression and myocardial injury and left ventricular remodeling in patients with myocardial infarction(MI).Methods A total of 80 patients with myocardial infarction(MI group)and 80 healthy subjects(control group)were selected.Left ventricular remodeling parameters(left ventricular end-diastolic diameter(LVEDD),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular ejection fraction(LVEF)),serum SFRP5,S100A4,lipoprotein-associated phospholipase A2(Lp-PLA2),and N-terminal pro-brain natriuretic peptide(NT-proBNP)levels were compared between the two groups.Results The LVESV,LVEDV,and LVEDD of the MI group were higher than those of the control group,while the LVEF was lower than that of the control group(P<0.05).The levels of Lp-PLA2,NT proBNP,SFRP5,and S100A4 in the MI group were higher than those in the control group(P<0.05).SFRP5 and S100A4 were significantly positively correlated with LVESV,LVEDV,LVEDD,Lp-PLA2 and NT-proBNP,and negatively correlated with LVEF(P<0.05).Conclusion The abnormal expression of serum SFRP5 and S100A4 in patients with myocardial infarction is closely related to myocardial injury and left ventricular remodeling.

关 键 词：SFRP5 S100A4 心肌梗死 心肌损伤 左心室重构 

分 类 号：R542.22[医药卫生—心血管疾病]