冠心病患者PCI术后不同时间血清miR-93-5p、IL-25水平变化及其与冠状动脉ISR的关系  

Relationship between serum miR-93-5p and IL-25 levels and coronary artery ISR in patients with coronary heart disease at different time after PCI

作　　者：张立杰[1] 王晓玲[1] 宋巧凤[1] 贾洪娟[1] 张振飞[1] 周文华[1] ZHANG lijie;WANG Xiaoling;SONG Qiaofeng;JIA Hongjuan;ZHANG Zhenfei;ZHOU Wenhua(Department of Cardiology,Tangshan People s Hospital,Tangshan 063001,Hebei,China)

机构地区：[1]唐山市人民医院心内科,河北唐山063001

出　　处：《中南医学科学杂志》2025年第1期110-113,共4页Medical Science Journal of Central South China

基　　金：河北省医学科学研究课题计划项目(20210316)。

摘　　要：目的探讨冠心病患者经皮冠状动脉介入(PCI)术后不同时间血清微小核糖核酸(miR)-93-5p、血清白细胞介素(IL)-25水平变化及其与冠状动脉支架内再狭窄(ISR)的关系。方法选取行PCI术的冠心病患者222例为研究对象,根据PCI术后复查冠状动脉造影结果将其分为ISR组30例和非ISR组192例,检测所有患者术前1天和术后24 h、7天、6个月的血清miR-93-5p、IL-25水平并进行比较。采用多因素Logistic回归分析法分析ISR发生的相关影响因素。结果术后7天ISR组的IL-25水平高于非ISR组(P<0.05)。ISR组术后24 h、7天IL-25水平较术前1天升高(P<0.05);非ISR组术后24 h IL-25水平较术前升高(P<0.05)。术后7天ISR组的血清miR-93-5p水平低于非ISR组(P<0.05)。ISR组术后24 h、7天血清miR-93-5p水平较术前1天降低(P<0.05);非ISR组术后24 h血清miR-93-5p水平较术前1天降低(P<0.05)。术后24 h及术后7天的IL-25水平是ISR发生的危险因素,术后24 h及术后7天的miR-93-5p水平是ISR发生的保护因素(P<0.05)。结论血清miR-93-5p、IL-25水平可作为预测冠心病患者PCI术后ISR的参考指标。Aim To investigate the correlation between serum microRNA(miR-93-5p)and serum interleukin(IL)-25 and in-stent restenosis(ISR)in patients with coronary heart disease at different time after percutaneous coronary intervention(PCI).Methods A total of 222 patients with coronary heart disease who underwent PCI were selected as the study objects,and were divided into ISR group(30 cases)and non-ISR group(192 cases)according to the coronary angiography reexamination results after PCI.Serum miR-93-5p and IL-25 levels of all patients were detected and compared 1 day before surgery and 24 hours,7 days and 6 months after surgery.The multiple logistic regression analysis was used to analyze the relevant influencing factors that lead to ISR occurrence.Results The level of IL-25 in the ISR group was significantly higher than that in the non-ISR group(P<0.05).In the ISR group,IL-25 levels at 24 h and 7 d after surgery were significantly higher than those at 1 d before surgery(P<0.05);In the non-ISR group,IL-25 levels were significantly higher 24 h after surgery than before(P<0.05).Intergroup comparison showed that the serum miR-93-5p level of the ISR group was significantly lower than that of the non-ISR group at 7 days after surgery(P<0.05).In the ISR group,the level of serum miR-93-5p at 24 h and 7 d after surgery was significantly lower than that at 1d before surgery(P<0.05).The level of serum miR-93-5p in the non-ISR group was significantly lower than that on the first day before surgery only 24 hours after surgery(P<0.05).The level of IL-2524 hours and 7 days after surgery was a risk factor for ISR,and the level of miR-93-5p 24 hours and 7 days after surgery was a protective factor for ISR(P<0.05).Conclusion Serum miR-93-5p and IL-25 levels can be used as reference indexes to predict ISR in patients with coronary heart disease after PCI.

关 键 词：miR-93-5p 白细胞介素-25 经皮冠状动脉介入治疗 支架内再狭窄 影响因素 

分 类 号：R541.4[医药卫生—心血管疾病]