糖尿病性心肌病患者血清Mst1水平与心功能、心肌纤维化的关系  

Relationship between serum Mst1 level and cardiac function and myocardial fibrosis in patients with diabetic cardiomyopathy

作　　者：张磊 简讯 邹强性 李林梅 ZHANG Lei;JIAN Xun;ZOU Qiangxing;LI Linmei(Mianyang Wanjiang Eye Hospital,Mianyang 621000,Sichuan,China;Sichuan Mianyang 404 Hospital,Mianyang 621000,Sichuan,China)

机构地区：[1]绵阳万江眼科医院,四川绵阳621000 [2]绵阳四○四医院,四川绵阳621000

出　　处：《中南医学科学杂志》2025年第1期122-124,177,共4页Medical Science Journal of Central South China

基　　金：四川省基层卫生事业发展研究中心项目(SWFZ18-Z-7)。

摘　　要：目的探讨糖尿病性心肌病(DCM)患者血清哺乳动物Ste20样激酶1(Mst1)水平与心功能、心肌纤维化的关系。方法选择2型糖尿病(T2DM)患者106例,按照是否发生DCM分为T2DM组54例(单纯T2DM)和DCM组52例。比较两组血清Mst1水平、心功能指标[舒张早期/舒张末期心室充盈速率(E/A)、左室射血分数(LVEF)、左室舒张末容积(LVEDV)、氨基末端脑钠肽前体(NT-proBNP)]、心肌纤维化指标[透明质酸(HA)、Ⅰ型前胶原(PCⅠ)、层粘连蛋白(LN)]。分析Mst1与心功能、心肌纤维化的关系。结果DCM组血清Mst1、HA、PCⅠ、LN、LVEDV、NT-proBNP水平高于T2DM组,E/A、LVEF低于T2DM组(P<0.05)。血清Mst1与E/A、LVEF呈负相关,与LVEDV、NT-proBNP、HA、PCⅠ、LN呈正相关(P<0.05)。结论DCM患者血清Mst1水平升高,与心功能、心肌纤维化指标存在相关关系。Aim To investigate the relationship between serum mammalian STE20-like kinase 1(Mst1)level and cardiac function and myocardial fibrosis in patients with diabetic cardiomyopathy(DCM).Methods 106 patients with type 2 diabetes mellitus(T2DM)were selected and divided into T2DM group(54 cases)and DCM group(52 cases)according to whether DCM occurred.Serum Mst1 level,cardiac function indexes(early/end diastolic ventricular filling rate(E/A),left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV),N-terminal pro-brain natriuretic peptide(NT-proBNP)),myocardial fibrosis indexes(hyaluronic acid(HA),type I procollagen(PCⅠ),layer adhesion protein(LN))were compared between the two groups.The relationship between Mst1 and cardiac function and myocardial fibrosis was analyzed.Results Serum levels of Mst1,HA,PCⅠ,LN,LVEDV and NT-proBNP in DCM group were higher than those in T2DM group,and E/A and LVEF were lower than those in T2DM group(P<0.05).Serum Mst1 was negatively correlated with E/A and LVEF,but positively correlated with LVEDV,NT-proBNP,HA,PCⅠand LN(P<0.05).Conclusion The serum Mst1 level in DCM patients is increased,which is correlated with cardiac function and myocardial fibrosis indexes.

关 键 词：糖尿病性心肌病 Mst1 心功能 心肌纤维化 

分 类 号：R587.2[医药卫生—内分泌]