南通市社区人群新型冠状病毒感染血清学监测结果分析  

Analysis of serological surveillance results of COVID-19 in community populations in Nantong City

作　　者：陆荣荣[1] 魏叶[1] 戴垚垚[1] 鲍超 刘巧[2] LU Rongrong;WEI Ye;DAI Yaoyao;BAO Chao;LIU Qiao(Department of Acute Infectious Diseases,Nantong Center for Disease Control and Prevention,Nantong,Jiangsu 226007,China;不详)

机构地区：[1]南通市疾病预防控制中心急性传染病科,江苏南通226007 [2]江苏省疾病预防控制中心慢性传染病防制所

出　　处：《医学动物防制》2025年第1期45-50,共6页Journal of Medical Pest Control

基　　金：江苏省卫生健康委科研项目(M2020020);南通市自然科学基金和社会民生科技计划(指导性)项目(MSZ2023118)。

摘　　要：目的了解社区人群血清新型冠状病毒感染特异性抗体水平变化特征,为预防再感染提供科学依据。方法选取崇川区、如东县、启东市作为监测点,分别于2022年12月、2023年3月和5月开展3轮监测,每个监测点每次采集血清人数不少于400人。用化学发光法进行S蛋白免疫球蛋白M(immunoglobulin M,IgM)、免疫球蛋白G(immunoglobulin G,IgG)、免疫球蛋白A(immunoglobulin A,IgA)检测。用SPSS 20.0软件对数据进行整理和分析,两个及以上样本均数比较采用方差分析(F检验),计数资料比较采用χ^(2)检验。结果首轮监测IgG阳性854人,阳性率为69.09%,近期感染292人,占23.62%;IgA阳性263人,阳性率为21.28%。第二轮监测IgM阳性41人,阳性率为3.39%;IgG阳性1108人,阳性率为91.57%。第三轮监测IgM阳性10人,阳性率为0.84%;IgG阳性1083人,阳性率为90.48%;IgA阳性698人,阳性率为58.31%。第二轮与第三轮监测IgM阳性率比较,差异有统计学意义(χ^(2)=18.910,P<0.001)。3轮监测的IgG阳性率比较,差异有统计学意义(χ^(2)=286.834,P<0.001)。第一轮和第三轮监测的IgA阳性率比较,差异有统计学意义(χ^(2)=2433.000,P<0.001)。结论2022年12月南通市有23.62%的人群近期感染新型冠状病毒,主城区人群、幼儿和小学生感染率较高。2023年3月IgG阳性率到达高峰,2023年5月略有下降,却仍维持较高水平,说明IgG的抗体应答可持续将近6个月,应继续加强疫情监测和免疫接种。Objective To understand the variation characteristics of serum COVID-19 specific antibody levels in community populations,and provide a scientific basis for preventing of reinfection.Methods Chongchuan District,Rudong County,and Qidong City were selected as the monitoring points,and the three rounds of surveillance were carried out in December 2022,March and May 2023,respectively,with the number of sera collected in each monitoring point not less than 400 people each time.Immunoglobulin M(IgM),immunoglobulin G(IgG),and immunoglobulin A(IgA)to S protein were detected by chemiluminescence assay.SPSS 20.0 software was used for collated and statistical analysis of data.The analysis of variance(F-test)was used to compare the mean of two or more samples,and the Chi-square test was used to compare the count data.Results A total of 854 people were positive for IgG in the first round of surveillance,the positive rate was 69.09%.Of these,292 cases(23.62%)were infected recently.Two hundred and sixty-three people IgA-positive,the positive rate of IgA was 21.28%.In the second round of surveillance,41 people were positive for IgM,the positive rate was 3.39%,and 1108 people were positive for IgG,the positive rate was 91.57%.In the third round of surveillance,10 people were positive for IgM,the positive rate was 0.84%.One thousand and eighty-three people were positive for IgG,with a positivity rate of 90.48%.Six hundred and ninety-eight people were positive for IgA,with a positivity rate of 58.31%.There was statistically significant difference in IgM positivity rate between the second and third rounds of surveillance(χ^(2)=18.910,P<0.001).The positive rate of IgG differences in three rounds of surveillance was significantly different(χ^(2)=286.834,P<0.001).The positive rate of IgA differences in the first round and the third round of surveillance was statistically significant(χ^(2)=2433.000,P<0.001).Conclusion In December 2022,23.62%of the population in Nantong City show recent infection with the SARS-CoV-2,with a higher infe

关 键 词：社区人群 IGM IGG IGA 新型冠状病毒感染 监测 分析 

分 类 号：R446.6[医药卫生—诊断学] R563.1[医药卫生—临床医学]