2015—2021年河北省健康人群风疹病毒抗体水平监测分析  

Monitoring and analysis of Rubella virus antibody levels in healthy population in Hebei Province from 2015 to 2021

作　　者：丛艳丽[1] 王伟[1] 杜慧[1] 郭玉[1] 崔世恒 孙丽[1] CONG Yanli;WANG Wei;DU Hui;GUO Yu;CUI Shiheng;SUN Li(Hebei Provincial Center for Disease Control and Prevention,Shijiazhuang,Hebei 050021,China)

机构地区：[1]河北省疾病预防控制中心,河北石家庄050021

出　　处：《医学动物防制》2025年第1期61-64,共4页Journal of Medical Pest Control

基　　金：河北省卫生健康委医学科学研究课题计划项目(20200694)。

摘　　要：目的了解2015—2021年河北省健康人群风疹病毒免疫球蛋白G(immunoglobulin G,IgG)水平分布情况,为河北省风疹的防控措施提供科学依据。方法2015—2021年采用分层随机抽样的方法采集健康人群血清样本,用酶联免疫吸附试验检测人群血清风疹病毒IgG水平。结果2015—2021年健康人群风疹病毒IgG阳性率为75.29%(3062/4067),风疹病毒抗体几何平均浓度(geometric mean concentration,GMC)为32.66IU/ml;2015—2019年河北省各地区健康人群风疹病毒IgG阳性率,差异有统计学意义(χ^(2)=44.88,P<0.05)。秦皇岛市健康人群风疹病毒IgG阳性率和GMC较高。2020—2021年河北省各地区人群风疹病毒IgG阳性率均不高;2015—2019年河北省健康人群风疹病毒IgG阳性率有降低趋势,2020—2021年健康人群风疹病毒IgG阳性率低于2015—2019年(χ^(2)=20.18,P<0.05)。2015—2019年0~<1岁和7~<15岁年龄组的风疹病毒IgG阳性率和GMC均较低,分别为63.09%(229/363)、68.04%(381/560)和21.14IU/ml、22.89IU/ml;2020—2021年0~<1岁、7~<15岁和15~<20岁年龄组的风疹病毒IgG阳性率和GMC均较低,分别为57.14%(92/161)、55.98%(103/184)、53.46%(85/159)和21.57IU/ml、20.26IU/ml、22.95IU/ml;≥20岁年龄组的风疹病毒IgG阳性率和GMC出现回升的现象。结论河北省健康人群风疹病毒抗体水平有待于进一步提高;0~<1岁、7~<15岁和15~<20岁年龄组的人群为感染风疹的高危人群。Objective To analyze the distribution of Rubella virus immunoglobulin G(IgG)levels in healthy population in Hebei Province from 2015 to 2021,providing a scientific basis for the prevention and control measure of rubella.Methods From 2015 to 2021,serum samples from healthy individuals were collected using stratified random sampling.Rubella virus IgG levels were measured using enzyme-linked immunosorbent assay.Results The overall Rubella virus IgG positivity rate of healthy population from 2015 to 2021 was 75.29%(3062/4067),geometric mean concentration(GMC)of Rubella virus antibody was 32.66IU/ml.From 2015 to 2019,the positivity rate of Rubella virus IgG were statistically significant among different areas in healthy population in Hebei Province(χ^(2)=44.88,P<0.05).Qinhuangdao showing higher positivity rate and GMC of Rubella virus IgG in healthy population.From 2020 to 2021,the positivity rates across different areas of Hebei were generally low.The positivity rate of Rubella virus IgG in healthy population in Hebei Province showed a decreasing trend from 2015 to 2019 and the positivity rate of Rubella virus IgG in healthy population was lower in 2020-2021 compared to 2015-2019(χ^(2)=20.18,P<0.05).From 2015 to 2019,the IgG positivity rates of Rubella virus and GMC were both lower in the 0-<1 year and 7-<15 years age groups,at 63.09%(229/363)and 68.04%(381/560)with GMC of 21.14IU/ml and 22.89IU/ml,respectively.In 2020-2021,the IgG positivity rates of Rubella virus and GMC were both lower in the 0-<1 year,7-<15 years,and 15-<20 years age groups,at 57.14%(92/161),55.98%(103/184),and 53.46%(85/159)with GMC of 21.57IU/ml,20.26IU/ml,and 22.95IU/ml,respectively.There was a rebound in IgG positivity rates and GMC in the≥20 years age group.Conclusion The Rubella virus antibody levels in the healthy population of Hebei Province need further improvement.Individuals in the 0-<1 year,7-<15 years,and 15-<20 years age groups are at higher risk for rubella infection.

关 键 词：风疹 健康人群 抗体水平 IGG 血清学监测 免疫效果 疫苗 

分 类 号：R186[医药卫生—流行病学]