sTREM-1 Ghrelin/Obestatin与胃癌术后肺部感染相关性及预测价值  

Correlation and Predictive Value of sTREM-1 and Ghrelin/Obestatin with Postoperative Pulmonary Infection in Gastric Cancer

作　　者：刘申芳 穆晓艳 胥晓萍 许彬 LIU Shenfang;MU Xiaoyan;XU Xiaoping(Rehabilitation University Qingdao Central Hospital/Qingdao Central Hospital,Shandong Qingdao 266000,China)

机构地区：[1]康复大学青岛中心医院/青岛市中心医院,山东青岛266000

出　　处：《河北医学》2025年第2期311-315,共5页Hebei Medicine

基　　金：山东省医药卫生科技发展计划项目,(编号:202204110044)。

摘　　要：目的:分析可溶性髓系细胞触发受体-1(sTREM-1)、胃饥饿素(Ghrelin)/肥胖抑制素(Obestatin)水平与胃癌术后肺部感染的相关性,并评价其对胃癌术后肺部感染的预测价值。方法:以2021年6月至2024年6月于本院接受胃癌手术的患者148例为研究对象,术后次日测定所有患者的血清sTREM-1、Ghrelin/Obestatin水平。术后随访1个月,依据患者的肺部感染情况分为感染组(n=65)和未感染组(n=83)。以受试者特征工作曲线(ROC)评价sTREM-1、Ghrelin/Obestatin水平对胃癌术后肺部感染的预测价值。结果:感染组的sTREM-1水平高于未感染组,Ghrelin/Obestatin水平低于未感染组(P<0.05)。ROC曲线显示,sTREM-1、Ghrelin/Obestatin水平单独预测胃癌术后肺部感染的曲线下面积(AUC)分别为0.773、0.761,灵敏度分别为64.62%、66.15%,特异度分别为84.34%、77.11%,联合预测的AUC为0.963,灵敏度为92.31%,特异度为90.36%,联合预测效能优于各指标单独预测(P<0.05)。结论:sTREM-1、Ghrelin/Obestatin水平与胃癌术后肺部感染密切相关,通过术后早期测定sTREM-1、Ghrelin/Obestatin水平可为胃癌术后肺部感染提供一定的预测价值。Objective:To analyze the correlation between soluble triggering receptor expressed on myeloid cells-1(sTREM-1),Ghrelin/Obestatin levels and postoperative pulmonary infection in gastric cancer,and evaluate their predictive value for postoperative pulmonary infection in gastric cancer.Methods:A total of 148 gastric cancer patients who underwent surgery at our hospital between June 2021 and June 2024 were enrolled.The serum levels of sTREM-1 and Ghrelin/Obestatin were measured on the day after surgery.The patients were followed up for 1 month postoperatively and divided into an infection group(n=65)and a non-infection group(n=83)based on the occurrence of pulmonary infection.The predictive value of sTREM-1 and Ghrelin/Obestatin levels for postoperative pulmonary infection was evaluated using receiver operating characteristic(ROC)curves.Results:The sTREM-1 level in the infection group was higher than that in the non-infection group,while the Ghrelin/Obestatin level in the infection group was lower than that in the non-infection group(P<0.05).The ROC curve showed that the area under the curve(AUC)for sTREM-1 and Ghrelin/Obestatin levels in predicting postoperative pulmonary infection in gastric cancer was 0.773 and 0.761,respectively,with sensitivity of 64.62% and 66.15%,and specificity of 84.34% and 77.11%,respectively.The AUC for combined prediction was 0.963,with sensitivity of 92.31% and specificity of 90.36%.The combined prediction performance was superior to that of individual markers(P<0.05).Conclusion:sTREM-1 and Ghrelin/Obestatin levels are closely associated with postoperative pulmonary infection in gastric cancer.Early measurement of these levels postoperatively may provide valuable predictive information for postoperative pulmonary infection in gastric cancer.

关 键 词：胃癌 术后肺部感染 可溶性髓系细胞触发受体-1 胃饥饿素/肥胖抑制素 预测价值 

分 类 号：R563.1[医药卫生—呼吸系统] R735.2[医药卫生—内科学]