老年H型高血压患者血清TSH颈动脉内膜厚度及PWV的相关性研究  

Study on the Correlation Between Serum TSH Carotid Intima-Media Thickness,and PWV in Elderly Patients with H-type Hypertension

作　　者：熊凌杰 梁立龙 李远远 陈劲 XIONG Lingjie;LIANG Lilong;LI Yuanyuan(Hefei Second People's Hospital,Anhui Hefei 230011,China)

机构地区：[1]安徽省合肥市第二人民医院老年医学科,安徽合肥230011

出　　处：《河北医学》2025年第2期326-330,共5页Hebei Medicine

基　　金：2019年安徽省重点研究与开发计划项目,(编号:201904a07020095)。

摘　　要：目的:观察老年H型高血压患者血清促甲状腺激素(TSH)水平及颈动脉内膜厚度(IMT)、脉搏波传导速度(PWV)变化情况,并分析它们之间的关联性。方法:纳入2021年4月至2024年5月本院收治的145例老年H型高血压患者,测量颈动脉IMT、PWV及TSH水平,并分析TSH水平、IMT、PWV三指标之间的相关性。结果:TSH异常患者IMT、PWV水平高于TSH正常患者,差异有统计学意义(P<0.05);IMT异常患者TSH、PWV水平高于IMT正常患者,差异有统计学意义(P<0.05);PWV异常患者TSH、IMT水平高于PWV正常患者,差异有统计学意义(P<0.05)。多元线性回归分析显示:病程、BMI及TSH是影响H型高血压患者IMT的影响因素(P<0.05);病程、BMI及TSH、IMT是影响H型高血压患者PWV的影响因素(P<0.05)。结论:老年H型高血压患者血清TSH水平异常与颈动脉IMT、PWV升高有关,可能是导致颈动脉硬化的相关因素。Objective:To observe the changes of serum thyroid stimulating hormone(TSH)level,carotid intima-media thickness(IMT)and pulse wave velocity(PWV)in elderly patients with H-type hypertension,and to analyze the association among them.Methods:A total of 145 elderly patients with H-type hypertension,admitted to our hospital from April 2021 to May 2024,were included.Carotid IMT,PWV,and TSH levels were measured,and the correlation between TSH levels,IMT,and PWV was analyzed.Results:The IMT and PWV levels in patients with abnormal TSH were higher than those in patients with normal TSH,with significant differences(P<0.05).The TSH and PWV levels in patients with abnormal IMT were higher than those in patients with normal IMT,with significant differences(P<0.05).The TSH and IMT levels in patients with abnormal PWV were higher than those in patients with normal PWV,with significant differences(P<0.05).Multiple linear regression analysis showed that disease duration,body mass index(BMI),and TSH were influencing factors for IMT in patients with H-type hypertension(P<0.05).Disease duration,BMI,TSH,and IMT were influencing factors for PWV in patients with H-type hypertension(P<0.05).Conclusion:Abnormal serum TSH levels in elderly patients with H-type hypertension are associated with increased carotid IMT and PWV,which may be related to the development of carotid atherosclerosis.

关 键 词：H型高血压 促甲状腺激素 颈动脉内膜厚度 脉搏波传导速度 动脉硬化 

分 类 号：R544.1[医药卫生—心血管疾病]