肠道微生物稳态失调对慢性肾脏病毒素的影响  

Effect of Intestinal Microbial Homeostasis Disorder on Chronic Kidney Disease Toxins

作　　者：黎瑜 王静 LI Yu;WANG Jing(Department of Nephrology,Luohu Hospital of Traditional Chinese Medicine,Shenzhen 518001,Guangdong,China)

机构地区：[1]深圳市罗湖区中医院肾病科,广东深圳518001

出　　处：《医学信息》2025年第3期184-187,共4页Journal of Medical Information

基　　金：深圳市科技计划项目(编号:KCXFZ20201221173612034)。

摘　　要：肠道微生物菌群在维持人体肠道内环境中的重要性逐渐得以揭示,其代谢产物直接参与慢性肾脏病尿毒症毒素积累。慢性肾脏病是由进行性毒素堆积引起贫血、容量负荷过重、电解质紊乱、矿物质和骨骼疾病和代谢性酸中毒等临床症状,其与肠道微生物群之间的相互作用越来越受关注。大量研究表明慢性肾脏病与肠道微生物稳态失衡的病理改变是通过上调产生特定有害毒素的微生物群丰度与减少产生有益产物的微生物群而互为因果。本文就肠道微生物变化及其代谢产物与慢性肾脏病尿毒症毒素之间的潜在相互作用进行综述,旨在为延缓肾功能进展提供临床治疗依据。The importance of gut microbiota in maintaining the internal environment of the human gut has gradually been revealed,and its metabolites are directly involved in the accumulation of uremic toxins in chronic kidney disease.Chronic kidney disease(CKD)is a clinical symptom caused by progressive toxin accumulation,such as anemia,volume overload,electrolyte imbalance,mineral and bone diseases,and metabolic acidosis.The interaction between CKD and gut microbiota has attracted more and more attention.A large number of studies have shown that the pathological changes of chronic kidney disease and intestinal microbial homeostasis imbalance are mutually causal by up-regulating the abundance of microflora that produce specific harmful toxins and reducing the microflora that produce beneficial products.This article reviews the potential interaction between intestinal microbial changes and their metabolites and uremic toxins in chronic kidney disease,aiming to provide clinical treatment basis for delaying the progression of renal function.

关 键 词：慢性肾脏病 肾功能不全 肠道微生物菌群 尿毒症毒素 

分 类 号：R259[医药卫生—中西医结合]