Prospects of synthetic biology in revolutionizing microbial synthesis and drug discovery  

作　　者：Emmanuel Chimeh Ezeako Abel Yashim Solomon Yemiode Bernard Itam Tobechukwu Christian Ezike Chinenye Peace Ogbonna Nnamdi Ginikachukwu Amuzie Emmanuel Chigozie Aham Cynthia Doowuese Aondover Gloria Oluchukwu Osuagwu Vincent Eric Ozougwu 

机构地区：[1]Department of Biochemistry,University of Nigeria,Nsukka 410001,Nigeria [2]College of Health Sciences,Nile University of Nigeria,Abuja 900001,Nigeria [3]Department of Biochemistry,Faculty of Basic Medical Sciences,University of Calabar,Calabar 540271,Nigeria [4]Department of Microbiology,University of Nigeria,Nsukka 410001,Nigeria [5]Department of Applied Biochemistry,Nnamdi Azikwe University,Awka 420110,Nigeria

出　　处：《Life Research》2025年第1期51-60,共10页TMR生命研究

摘　　要：Synthetic biology(SynBio)is an emerging field of study with great potential in designing,engineering,and constructing new microbial synthetic cells that do not pre-exist in nature or re-engineering existing cells to accomplish industrial purposes.Systems biology seeks to understand biology at multiple dimensions,beginning with the molecular and cellular level and progressing to the tissues and organismal level and characterizes cells as complex information-processing systems.SynBio,on the other hand,toggles further and strives to develop and create its systems from scratch.SynBio is now applied in the development of novel therapeutic drugs for the prevention of human diseases,scale up industrial processes,and accomplish previously unfeasible industrial outcomes.This is made possible through significant breakthroughs in DNA sequencing and synthesis technology,as well as insights gained from synthetic chemistry and systems biology.SynBio technologies have allowed for the introduction of improved and synthetic metabolic functionalities in microorganisms to enable the synthesis of a range of pharmacologically-relevant compounds for pharmaceutical exploration.SynBio applications range from finding new ways to making industrial chemical synthesis processes more sustainable as well as the microbial synthesis of improved therapeutic modalities.Hence,this study underpins several innovations,auspicious potentials,and future directions afforded by SynBio that proposes improved industrial microbial synthesis for pharmaceutical exploration.

关 键 词：synthetic biology drug discovery microbial synthesis sustainable development genetic circuit gene editing 

分 类 号：Q819[生物学—生物工程]