子痫前期患者血浆胎盘生长因子、D-二聚体和C反应蛋白水平及其诊断价值  

Plasma placental growth factor,D-dimer and C-reactive protein levels and their diagnostic value in patients with preeclampsia

作　　者：张凤美[1] 刘树业[1] ZHANG Feng-Mei;LIU Shu-Ye(The Third Central Hospital of Tianjin,Tianjin Key Laboratory of In vitro Life Support for Severe Diseases,Tianjin Artificial Cell Engineering Technology Research Center,Tianjin Institute of Hepatobiliary Diseases,Tianjin 300170,China)

机构地区：[1]天津市第三中心医院、天津重症疾病体外生命支持重点实验室、天津市人工细胞工程技术研究中心、天津市肝胆疾病研究所,天津300170

出　　处：《吉林医学》2025年第3期530-533,共4页Jilin Medical Journal

基　　金：天津市医学重点学科(专科)建设项目资助[项目编号:TJYXZDXK-047A]。

摘　　要：目的:探讨子痫前期(PE)患者血浆胎盘生长因子(PLGF)、D-二聚体(D-D)和C反应蛋白(CRP)水平在PE中的诊断价值。方法:选取2023年1~8月天津市第三中心医院82例确诊PE患者为观察对象,按病情严重程度分为重度PE组(sPE组)40例与轻度PE组(mPE组)42例,同时选取44例健康孕妇为对照组。比较各组之间血浆PLGF、D-D和CRP水平的差异。并利用SPSS19.0统计学软件进行数据统计分析,绘制ROC曲线检测其对PE的诊断效能。结果:sPE组、mPE组PLGF与对照组比较,差异均有统计学意义(P<0.01)。随着PE病情的发展,血浆PLGF水平呈下降趋势;sPE组、mPE组D-D、CRP与对照组比较,差异均有统计学意义(P<0.01)。随着PE病情的发展,血浆D-D和CRP水平呈上升趋势;PLGF、D-D和CRP曲线下面积(AUC)分别为0.902、0.922和0.810,三者联合检测阳性率(AUC=0.967)高于单项检测阳性率。结论:血浆PLGF、D-D和CRP水平能反应PE患者的病情严重程度,可作为PE早期诊断的有效指标,且三者联合可提高PE的诊断效能。Objective To investigate the diagnostic value of plasma placental growth factor(PLGF),D-dimer(D-D)and C-reactive protein(CRP)levels in the patients with preeclampsia(PE).Methods A total of 82 patients with confirmed PE were selected as the observation group and divided into severe PE group(sPE group,n=40)and mild PE group(mPE group,n=42)based on the severity of the disease.Meanwhile,44 healthy pregnant women were chosen as the control group.The levels of plasma PLGF,D-D,and CRP were compared among the groups.Data were statistically analyzed by using SPSS19.0 software,and ROC curves were drawn to assess the diagnostic efficacy for PE.Results Compared with the control group,there were statistically significant differences in PLGF levels between the sPE group and mPE group(P<0.01),with a downward trend in PLGF levels as PE progressed.Similarly,there were significant differences in D-D and CRP levels between the sPE group,mPE group,and control group(P<0.01),with an upward trend in D-D and CRP levels as PE progressed.The areas under the ROC curve(AUC)for PLGF,D-D,and CRP were 0.902,0.922,and 0.810,respectively.The positive rate of combined detection(AUC=0.967)was higher than that of single detection.Conclusions The levels of plasma PLGF,D-D,and CRP could reflect the severity of PE and serve as effective indicators for the early diagnosis of PE.Moreover,the combination of these three markers could enhance the diagnostic efficiency of PE.

关 键 词：胎盘生长因子 D-二聚体 C反应蛋白 

分 类 号：R714.245[医药卫生—妇产科学]