免疫增强型肠内营养乳剂对老年感染性休克患者营养状况及肠黏膜屏障功能的影响  

Effects of immune-enhanced enteral nutrition emulsion on nutritional status and intestinal mucosal barrier function in elderly patients with septic shock

作　　者：林彩霞[1] 刘海金 赖玲治 LIN Cai-Xia;LIU Hai-Jin;LAI Ling-Zhi(Department of Intensive Care Nursing,the First Hospital of Quanzhou,Fujian,China)

机构地区：[1]福建医科大学附属泉州市第一医院护理部,福建泉州362011 [2]福建医科大学附属泉州市第一医院EICU,福建泉州362011 [3]福建医科大学附属泉州市第一医院重症医学科,福建泉州362011

出　　处：《吉林医学》2025年第3期700-704,共5页Jilin Medical Journal

基　　金：泉州市科学技术局科技计划项目[项目编号:2023NS056]。

摘　　要：目的:探究免疫增强型肠内营养乳剂对老年感染性休克患者营养状况及肠黏膜屏障功能的影响。方法:选取福建医科大学附属泉州市第一医院2021年5月~2024年5月收治的66例老年感染性休克患者,随机分为两组,每组各33例,其中对照组采用普通肠内营养制剂干预,研究组予免疫增强型肠内营养制剂干预,评估两组营养状态、炎性因子水平、肠道黏膜屏障指标、免疫指标、预后情况。结果:治疗前两组血清白蛋白(ALB)、前白蛋白(PAB)、血红蛋白(HGB)比较,差异无统计学意义(P>0.05);治疗前两组肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)、降钙素原(PCT)比较,差异无统计学意义(P>0.05)。治疗后研究组TNF-α、CRP、PCT低于对照组,差异有统计学意义(P<0.05);治疗后研究组内毒素、二胺氧化酶、CD8^(+)水平低于对照组,差异有统计学意义(P<0.05);治疗后研究组ALB、PAB、HGB、CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,差异有统计学意义(P<0.05)。结论:免疫增强型肠内营养乳剂应用于老年感染性休克患者效果较好,可改善老年患者营养状况、肠黏膜屏障功能、免疫功能,降低患者炎性因子水平。Objective To investigate the effects of immune-enhanced enteral nutrition emulsion on nutritional status and intestinal mucosal barrier function in elderly patients with septic shock.Methods Sixty-six elderly patients with septic shock admitted to the the First Hospital of Quanzhou affiliated to Fujian medical university between May 2021 and May 2024 were selected and randomly divided into two groups of 33 patients each.The control group received intervention with standard enteral nutrition formulations,while the study group received intervention with immune-enhancing enteral nutrition formulations.The nutritional status,levels of inflammatory factors,intestinal mucosal barrier indicators,immune indicators,and prognosis were assessed in both groups.Results Before treatment,there were no significant differences in serum albumin(ALB),prealbumin(PAB),hemoglobin(HGB),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),and procalcitonin(PCT)between the two groups(P>0.05).After treatment,the study group had significantly lower levels of TNF-α,CRP,PCT,endotoxin,diamine oxidase,and CD8^(+)compared to the control group(P<0.05).Additionally,ALB,PAB,HGB,CD3^(+),CD4^(+),and CD4^(+)/CD8^(+)levels were significantly higher in the study group than in the control group(P<0.05).Conclusions Immune-enhanced enteral nutrition emulsion has a good effect on elderly patients with septic shock.It can improve nutritional status,intestinal mucosal barrier function,immune function,as well as reduce the levels of inflammatory factors in elderly patients.

关 键 词：肠内营养 感染性休克 营养状态 肠黏膜屏障 老年 

分 类 号：R631.4[医药卫生—外科学]