低密度中性粒细胞在病毒感染性疾病中的作用与机制研究进展  

Progress in the role and mechanism of low-density neutrophils in viral infectious diseases

作　　者：王时佳 张宇丝 马樱 张春梅 许晓悦 左佳佳 张赟 张正祥[1] WANG Shijia;ZHANG Yusi;MA Ying;ZHANG Chunmei;XU Xiaoyue;ZUO Jiajia;ZHANG Yun;ZHANG Zhengxiang(Department of Immunology,Medical school of Yan’an university,716000,China)

机构地区：[1]延安大学医学院免疫学教研室,716000 [2]空军军医大学基础医学院免疫学教研室,西安710032

出　　处：《传染病信息》2025年第1期93-97,共5页Infectious Disease Information

基　　金：国家自然科学基金项目(82272331,82341071);陕西省自然科学基础研究计划面上项目(2023-JC-YB-640);陕西省自然科学基础研究计划重点项目(2022JZ-45)。

摘　　要：低密度中性粒细胞是中性粒细胞的重要亚群,由不同来源和成熟度的中性粒细胞组成,并在表型和功能上具有异质性和多样性。在病毒感染性疾病中,低密度中性粒细胞可来源于骨髓造血干细胞或者外周成熟中性粒细胞,并因病毒感染类型不同,发挥抗病毒或免疫抑制作用,与疾病的转归和预后密切相关。本文主要总结了低密度中性粒细胞在病毒感染性疾病中的作用及机制的研究进展,为以中性粒细胞为靶点的病毒感染治疗提供新的思路。Low-density neutrophils(LDN)represent a significant subset of neutrophils,comprising neutrophils of diverse origins and maturation stages,and exhibiting heterogeneity and diversity in phenotype and function.In viral infectious diseases,LDN can originate from hematopoietic stem cells within the bone marrow or from mature peripheral neutrophils.Depending on the type of viral infection,LDN can exert either antiviral or immunosuppressive effects,which are closely associated with the progression and prognosis of the disease.This review aims to summarize the research progress on the roles and mechanisms of LDN in viral infectious diseases,providing new insights for therapeutic strategies targeting neutrophils in viral infections.

关 键 词：低密度中性粒细胞 病毒感染性疾病 表型 功能 

分 类 号：R34[医药卫生—基础医学]