基于结构-功能连接耦合分析脑卒中后功能障碍的研究进展  

Advances in structural-functional connectivity coupling analysis for understanding post-stroke functional impairments

作　　者：方圣杰 刘再兴 吴亚男 洪文军 徐蓉[1] FANG Shengjie;LIU Zaixing;WU Yanan;HONG Wenjun;XU Rong(Department of Rehabilitation Medicine,Nanjing Drum Tower Hospital Clinical College of Jiangsu University,Nanjing 210008,China;Department of Rehabilitation Medicine,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China)

机构地区：[1]江苏大学鼓楼临床医学院康复医学科,南京210008 [2]南京大学医学院附属鼓楼医院康复医学科,南京210008

出　　处：《磁共振成像》2025年第2期119-123,129,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金项目(编号:82002378);南京鼓楼医院临床研究专项资金项目(编号:2022-LCYJ-PY-27)。

摘　　要：脑卒中作为常见的神经系统疾病,可导致多种功能障碍,严重影响患者的生活质量。结构连接(structural connectivity,SC)和功能连接(functional connectivity,FC)及其耦合分析在揭示脑卒中后功能障碍的神经机制方面受到了广泛关注。本文通过总结SC和FC的基本原理及其机制,阐述SC-FC耦合分析的基本原理,并重点探讨SC-FC耦合分析应用于脑卒中后的运动功能障碍、认知功能障碍以及情绪障碍的作用。通过研究大脑SC和FC的耦合关系以深入探索脑卒中后功能障碍的神经机制,能够更加系统地分析功能障碍的严重程度和康复潜力的潜在神经影像学特征,为脑卒中后功能障碍的个性化治疗提供新思路。As a prevalent neurological disorder,stroke can result in a variety of functional impairments,significantly impacting patients'quality of life.Structural connectivity(SC)and functional connectivity(FC),along with the SC-FC connectivity coupling analysis,have garnered considerable attention in the research of uncovering the neural mechanisms underlying post-stroke functional impairments.This review outlines the fundamental principles of SC-FC connectivity coupling analysis by summarizing the fundamentals of SC and FC and their mechanisms,and focus on the role of SC-FC connectivity coupling analysis applied to motor dysfunction,cognitive dysfunction,and mood disorders after stroke.By evaluating the coupling relationship between SC and FC,we can systematically analyze the potential neuroimaging features of the severity of dysfunction and rehabilitation potential.In turn,it can provide novel ideas for the personalized rehabilitation strategies for post-stroke patients.

关 键 词：脑卒中 功能障碍 磁共振成像 结构-功能连接耦合 神经影像学 神经康复 

分 类 号：R445.2[医药卫生—影像医学与核医学] R743.3[医药卫生—诊断学]