基于动脉自旋标记的血脑屏障评估方法在中枢神经系统疾病中的研究进展  

Research progress of blood-brain barrier evaluation methods based on arterial spin labeling in central nervous system diseases

作　　者：李梦瑶 张浩[1] 曹际斌[1] LI Mengyao;ZHANG Hao;CAO Jibin(Department of Radiology,the First Hospital of China Medical University,Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院放射科,沈阳110001

出　　处：《磁共振成像》2025年第2期142-148,共7页Chinese Journal of Magnetic Resonance Imaging

摘　　要：血脑屏障(blood-brain barrier,BBB)是神经血管单元的关键组成部分,对维持中枢神经系统的稳态至关重要,其功能损伤与多种神经系统疾病相关。动脉自旋标记(arterial spin labelling,ASL)技术作为一种无创的磁共振成像(magnetic resonance imaging,MRI)方法,以水质子作为天然的内源性示踪剂,通过监测ASL信号从微血管到脑组织的交换,评估BBB的功能状态。本文将对三种基于ASL的BBB评估技术在阿尔茨海默病(Alzheimer's disease,AD)、镰状细胞病(sickle cell disease,SCD)、脱髓鞘疾病、脑小血管疾病(cerebral small vessel disease,CSVD)和精神分裂症谱系障碍(schizophrenia spectrum disorder,SSD)中的应用进行讨论,以期为研究者使用该技术研究中枢神经系统疾病中BBB的功能损伤提供重要参考。The blood-brain barrier(BBB)is a critical component of the neurovascular unit and is crucial for maintaining the stability of the central nervous system.Its dysfunction is associated with various neurological disorders.Arterial spin labeling(ASL)technology,a non-invasive magnetic resonance imaging(MRI)method,uses water protons as a natural endogenous tracer.By monitoring the exchange of ASL signals from microvessels to brain tissue,it assesses the functional status of the BBB.This article will discuss the application of three BBB assessment techniques based on ASL in Alzheimer's disease(AD),sickle cell disease(SCD),demyelinating diseases,cerebral small vessel disease(CSVD),and schizophrenia spectrum disorder(SSD),with the aim of providing important references for researchers to use these techniques to study the functional impairment of BBB in central nervous system diseases.

关 键 词：阿尔茨海默病 镰状细胞病 磁共振成像 动脉自旋标记 血脑屏障 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.5[医药卫生—诊断学]