瘤周影像组学在胶质瘤中的研究进展  

Advances in the application of peritumoral radiomics in gliomas

作　　者：欧阳群慧 华克磊 方来平 詹文峰 王伟[1] 周天星 江桂华 刘萍[1] OUYANG Qunhui;HUA Kelei;FANG Laiping;ZHAN Wenfeng;WANG Wei;ZHOU Tianxing;JIANG Guihua;LIU Ping(Imaging Center,the Affiliated Guangdong Second Provincial People's Hospital of Jinan University,Guangzhou 510317,China)

机构地区：[1]暨南大学附属广东省第二人民医院影像中心,广州510317

出　　处：《磁共振成像》2025年第2期149-153,164,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：国家自然科学基金青年科学基金项目(编号:82102004);广州市科技计划项目(编号:2023A03J0276)。

摘　　要：胶质瘤是颅内最常见的原发肿瘤,手术是其一线治疗方案,术后复发患者90%发生于瘤周脑区(peritumoral brain zone,PBZ)。PBZ是肿瘤组织与正常脑组织的交界区,是肿瘤微环境的重要部分并反映对周围组织的浸润行为。深入认识和挖掘PBZ的生物学信息对改善胶质瘤患者预后至关重要。近年来,影像组学在胶质瘤的分级、分子分型及预后评估等应用方面已取得显著进展,但主要聚焦于肿瘤实体部分。随着研究的深入,PBZ在胶质瘤生物学行为评估中的重要性逐渐被揭示,PBZ影像组学的研究逐渐成为热点。本文从PBZ的概念、意义及瘤周影像组学在胶质瘤中的应用包括鉴别诊断、分子分型、术后复发预测、预后预测等方面的研究进展进行综述,旨在提高对胶质瘤PBZ的认识,并为开展其相关研究提供思路和线索,最终为患者精准管理策略提供依据。Glioma represents the most prevalent primary intracranial neoplasm,and surgical resection constitutes the preferred primary therapeutic regimen.Approximately 90%of postoperative recurrences in glioma patients occur within the peritumoral brain zone(PBZ),which serves as the boundary between tumor tissue and adjacent normal brain tissue.The PBZ is a pivotal component of the tumor microenvironment and provides insights into the invasive behavior of glioma towards surrounding tissues.A comprehensive understanding and exploration of the biological information contained within the PBZ are crucial for improving the prognosis of glioma patients.In recent years,radiomics has made significant progress in applications such as glioma grading,genotyping,and prognostic evaluation,but primarily focusing on the solid component.As research advances,the importance of the PBZ in assessing the biological behavior of gliomas has gradually come to light,rendering radiomic studies of the PBZ a key area of investigation.This article reviews the concept and significance of the PBZ,along with the advancements in the utilization of peritumoral radiomics in gliomas,including differential diagnosis,molecular typing,prediction of postoperative recurrence and prognosis prediction.The objective is to enhance the understanding of PBZ in gliomas,provide insights and guidelines for conducting pertinent research,and ultimately establish a foundation for precise management strategies for patients.

关 键 词：胶质瘤 瘤周脑区 影像组学 磁共振成像 人工智能 

分 类 号：R445.2[医药卫生—影像医学与核医学] R730.264[医药卫生—诊断学]