中脑导水管狭窄引起脑脊液循环障碍的计算流体动力学分析  

Disorder of Cerebrospinal Fluid Circulation Induced by Mesencephalic Aqueduct Stenosis:A Computational Fluid Dynamics Analysis

作　　者：祝续 吴保鹏 郭晓远 陈强[1] ZHU Xu;WU Baopeng;GUO Xiaoyuan;CHEN Qiang(School of Biological Science&Medical Engineering,Southeast University,Nanjing 211189,China;Department of Neurosurgery,Zhongda Hospital,Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学生物科学与医学工程学院,南京211189 [2]东南大学附属中大医院神经外科,南京210009

出　　处：《医用生物力学》2025年第1期202-209,共8页Journal of Medical Biomechanics

基　　金：国家自然科学基金面上项目(32170137)。

摘　　要：目的 探究中脑导水管狭窄不同程度对颅内脑脊液流场的影响。方法 基于1名志愿者的临床磁共振影像序列,利用半自动图像分割方法,重建完整的正常脑脊液循环模型。在此基础上构建8个理想的中脑导水管狭窄模型。使用计算流体动力学方法,模拟9个模型的脑脊液流场。结果 随着中脑导水管狭窄度增加,其上、下游最大压力差也相应增加,且脑脊液的流速加快。正常模型中,中脑导水管上、下游最大压力差为0.84 Pa,最大流速为11.4 mm/s;而最大狭窄度模型中,最大压力差为21.36 Pa,最大流速为60.3 mm/s。相较于正常模型,最大压力差和最大流速分别提高了约25倍和5倍。同时,压力差与中脑导水管狭窄处横截面积平方呈反比例关系,且与狭窄处脑脊液最大流速的二次方呈线性关系。结论 低狭窄度中脑导水管上、下游压力差和流速增加不显著,而高狭窄度提高了脑积水发病的风险。研究结果为理解梗阻性脑积水和颅内高压的形成奠定了一定理论基础。Objective To study the effects from varying stenosis degrees of the mesencephalic aqueduct on intracranial cerebrospinal fluid(CSF)flow field.Methods Based on the clinical magnetic resonance image sequences of a male volunteer,a complete normal CSF circulation model was reconstructed by using semi-automated image segmentation technique.Subsequently,eight ideal models representing different stenosis degrees of the mesencephalic aqueduct were manually created.Computational fluid dynamics(CFD)was then performed to simulate the CSF flow field in the nine models.Results The stenosis degree of the mesencephalic aqueduct was positively correlated with the maximum pressure difference between the aqueduct upstream and downstream and the maximum velocity of CSF within the stenosed aqueduct.In the normal model,the maximum pressure difference was 0.84 Pa and the maximum velocity was 11.4 mm/s.While in the maximum stenosed model,the maximum pressure difference and velocity were 21.36 Pa and 60.3 mm/s,respectively.Compared to the normal model,the maximum pressure difference and velocity were approximately increased by 25 times and 5 times,respectively.Moreover,the maximum pressure difference was inversely proportional to the stenosis area square of the aqueduct,and there was a linear relationship between the pressure difference and the quadratic of the maximun CSF velocity.Conclusions The pressure difference and velocity of the stenosed mesencephalic aqueduct was not apparently increased with mild stenosis with respect to the normal aqueduct,while the great aqueductal stenosis increased the risk of hydrocephalus.This study provides a theoretical framework which contributes to understanding the development of obstructive hydrocephalus and intracranial hypertension.

关 键 词：脑积水 颅内高压 中脑导水管狭窄 计算流体动力学 

分 类 号：R318.01[医药卫生—生物医学工程]