SF、FT4在甲状腺功能正常的2型糖尿病合并非酒精性脂肪肝患者中的应用价值  

Application values of SF and FT4 in individuals with type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease and in a normal thyroid function

作　　者：王芸 郑盼盼 闵玺 常湛[1] 张莉莉[1] WANG Yun;ZHENG Panpan;MIN Xi(Department of Endocrinology,Shijiazhuang Second Hospital,Hebei,Shijiazhuang 050000,China;不详)

机构地区：[1]河北省石家庄市第二医院内分泌科,050000 [2]河北省石家庄市高新区长江社区卫生服务中心

出　　处：《河北医药》2025年第2期254-257,262,共5页Hebei Medical Journal

基　　金：河北省卫生健康委员会重点科技研究计划(编号:20241865)。

摘　　要：目的探究铁蛋白(SF)和游离甲状腺素(FT4)在2型糖尿病(T2DM)并发非酒精性脂肪肝(NAFLD)诊断中的应用价值。方法随机选取2020年12月至2021年12月石家庄市第二医院收治的T2DM患者共165例为研究对象,根据超声定量脂肪含量的结果将患者分为单纯T2DM组(对照组,n=47)和T2DM并发NAFLD组(NAFLD组,n=118)。比较2组患者的一般临床生化、肿瘤标志物及甲状腺激素指标,采用多因素二元Logistic回归分析影响T2DM并发NAFLD的独立危险因素,绘制受试者工作特征(ROC)曲线并以ROC曲线下面积(AUC)、敏感度及特异度等评估SF、FT4及二者联合在诊断T2DM并发NAFLD中的应用价值。结果NAFLD组患者体重指数(BMI)、C肽、三酰甘油(TG)、TG/高密度脂蛋白胆固醇(HDL-C)水平均高于对照组,差异有统计学意义(P<0.05)。NAFLD组SF水平高于对照组(P<0.05)。NAFLD组FT4水平低于对照组(P<0.05)。多因素二元Logistic回归分析显示SF和FT4是导致T2DM并发NAFLD的独立危险因素。SF、FT4二者联合预测T2DM患者并发NAFLD的能力优于单独检测。结论SF和FT4二者联合在评估T2DM患者并发NAFLD方面具有积极作用。Objective To explore the application values of serum ferritin(SF)and free thyroxine(FT4)in the diagnosis of type 2 diabetes mellitus(T2DM)complicated with non-alcoholic fatty liver disease(NAFLD).Methods A total of 165 T2DM patients admitted to Shijiazhuang Second Hospital from December 2020 to December 2021 were randomly selected and divided into simple T2DM group(control group,n=47)and T2DM complicated with NAFLD group(NAFLD group,n=118)according to the results of quantitative ultrasound fat content.The general clinical biochemical,tumor markers and thyroid hormone indexes were compared between the two groups.The independent risk factors of T2DM complicated with NAFLD were analyzed by multivariate binary Logistic regression analysis.The receiver operating characteristic(ROC)curve was plotted,and the area under the curve(AUC),sensitivity and specificity were calculated to evaluate the application values of SF,FT4 and their combination in diagnosing T2DM complicated with NAFLD.Results Body mass index(BMI),C-peptide,triglyceride(TG)and TG/high-density lipoprotein-cholesterol(HDL-C)in NAFLD group were significantly higher than those of control group(P<0.05).Compared with the control group,the SF level in NAFLD group was significantly increased(P<0.05),and the level of FT4 was significantly decreased(P<0.05).Multivariate binary Logistic regression analysis showed that SF and FT4 were independent risk factors for NAFLD in T2DM patients.A combination detection of SF and FT4 in predicting T2DM complicated NAFLD was superior to that of a single detection.Conclusion The combination detection of SF and FT4 plays a positive role in evaluating T2DM complicated with NAFLD.

关 键 词：2型糖尿病 非酒精性脂肪肝 铁蛋白 游离甲状腺素 

分 类 号：R587.1[医药卫生—内分泌]