逆转MRSA的抗菌药物耐药性的研究进展  

Research progress in reversing antimicrobial resistance of methicillin-resistant Staphylococcus aureus infection

作　　者：游顺杰 贾艾敏 黎思 蔡燕[1] 向小燕[1] YOU Shunjie;JIA Aimin;LI Si(Affiliated Hospital of North Sichuan Medical College,Sichuan,Nanchong 637000,China;不详)

机构地区：[1]川北医学院附属医院,四川省南充市637000 [2]川北医学院风湿免疫研究所

出　　处：《河北医药》2025年第2期307-312,共6页Hebei Medical Journal

基　　金：四川省医学会伤口(泰阁)专项课题(编号:2022TG05)。

摘　　要：耐甲氧西林金黄色葡萄球菌(MRSA)的治疗一直是临床上的重要难题。目前越来越多的实验证据表明,根据目前已知的MRSA的耐药机制,逆转MRSA的抗菌药物耐药性从而恢复MRSA对抗菌药物的敏感性是治疗MRSA的一条重要途径。本文就目前MRSA已明确的主要耐药机制,以及关于能逆转MRSA的抗菌药物耐药性的最新治疗药物与方法作一综述。The treatment of methicillin-resistant Staphylococcus aureus(MRSA)infection has been a significant clinical challenge.Increasing experimental evidence suggests that reversing the antibiotic resistance of MRSA infection,based on the known resistance mechanisms,is an important approach to restore its sensitivity to antimicrobial drugs.This article provided a comprehensive review of the current major resistance mechanisms of MRSA infection and the latest treatment drugs and methods to reverse antibiotic resistance of MRSA infection.

关 键 词：抗菌药物 逆转耐药性 综述 

分 类 号：R978[医药卫生—药品]