血清sTNFR-Ⅰ、CEACAM6、BK在宫颈上皮内瘤变及宫颈癌患者中的水平及意义  

Levels and significance of serum sTNFR-Ⅰ,CEACAM6 and BK in cervical intraepithelial neoplasia and cervical cancer patients

作　　者：王晓玲[1] 刘飞[2] WANG Xiaoling;LIU Fei(Department of Obstetrics and Gynecology,the Fourth People′s Hospital of Zigong,Zigong,Sichuan 643000,China;Department of General Medicine,the Fourth People′s Hospital of Zigong,Zigong,Sichuan 643000,China)

机构地区：[1]四川省自贡市第四人民医院妇产科,四川自贡643000 [2]四川省自贡市第四人民医院全科医学科,四川自贡643000

出　　处：《检验医学与临床》2025年第5期645-650,共6页Laboratory Medicine and Clinic

基　　金：四川省医学(青年创新)科研课题项目(S20193)。

摘　　要：目的探讨血清可溶性肿瘤坏死因子受体Ⅰ(sTNFR-Ⅰ)、癌胚抗原相关细胞黏附分子6(CEACAM6)、缓激肽(BK)在不同程度宫颈上皮内瘤变(CIN)及宫颈癌患者中的水平及意义。方法选取2021年8月至2023年8月该院收治的104例宫颈癌患者作为癌变组,104例CIN患者作为CIN组,另选取同期该院104例女性健康体检者作为对照组。比较癌变组、CIN组、对照组,以及不同CIN分级患者血清sTNFR-Ⅰ、CEACAM6、BK水平。采用Spearman相关分析CIN患者血清sTNFR-Ⅰ、CEACAM6、BK水平与CIN分级的相关性。采用受试者工作特征(ROC)曲线分析血清sTNFR-Ⅰ、CEACAM6、BK对CIN及宫颈癌的诊断价值。采用危险度分析不同血清sTNFR-Ⅰ、CEACAM6、BK水平患者发生CIN及宫颈癌的情况。结果癌变组、CIN组血清sTNFR-Ⅰ、CEACAM6、BK水平均高于对照组,且癌变组均高于CIN组,差异均有统计学意义(P<0.05)。CINⅢ级和CINⅡ级患者血清sTNFR-Ⅰ、CEACAM6、BK水平均高于CINⅠ级患者,且CINⅢ级患者均高于CINⅡ级患者,差异均有统计学意义(P<0.05)。Spearman相关分析结果显示,CIN患者血清sTNFR-Ⅰ、CEACAM6、BK水平与CIN分级均呈正相关(r=0.711、0.683、0.704,P<0.05)。ROC曲线分析结果显示,血清sTNFR-Ⅰ、CEACAM6、BK联合检测诊断CIN及宫颈癌的曲线下面积分别为0.926、0.922。危险度分析结果显示,血清sTNFR-Ⅰ、CEACAM6、BK高表达患者发生CIN的风险分别是低表达患者的2.000、1.884、6.875倍;血清sTNFR-Ⅰ、CEACAM6、BK阳性表达患者发生宫颈癌的风险分别是阴性表达患者的5.077、4.783、4.818倍。结论CIN患者血清sTNFR-Ⅰ、CEACAM6、BK水平均低于宫颈癌患者,各项指标联合检测对CIN及宫颈癌均有一定诊断价值,且CIN患者各项指标水平与CIN分级均呈正相关,可作为临床诊断疾病、评估病情的辅助指标。Objective To investigate the levels and significance of serum soluble tumor necrosis factor receptorⅠ(sTNFR-Ⅰ),carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)and bradykinin(BK)in patients with different degrees of cervical intraepithelial neoplasia(CIN)and cervical cancer.Methods A total of 104 patients with cervical cancer admitted to the hospital from August 2021 to August 2023 were selected as the cancerization group,104 patients with CIN were selected as the CIN group,and 104 female healthy physical examination subjects in the hospital during the same period were selected as the control group.The serum levels of sTNFR-Ⅰ,CEACAM6 and BK in cancer group,CIN group,control group and different CIN grades were compared.Spearman correlation analysis was used to analyze the correlation between serum sTNFR-Ⅰ,CEACAM6,BK levels and CIN grading in CIN patients.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum sTNFR-Ⅰ,CEACAM6 and BK for CIN and cervical cancer.The incidence of CIN and cervical cancer in patients with different serum levels of sTNFR-Ⅰ,CEACAM6 and BK were analyzed by risk stratification.Results The serum levels of sTNFR-Ⅰ,CEACAM6 and BK in the cancer group and the CIN group were higher than those in the control group,and those in the cancer group were higher than those in the CIN group,and the differences were statistically significant(P<0.05).The serum levels of sTNFR-Ⅰ,CEACAM6 and BK in CINⅢand CINⅡpatients were higher than those in CINⅠpatients,and those in CINⅢpatients were higher than those in CINⅡpatients,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that serum sTNFR-Ⅰ,CEACAM6 and BK levels were positively correlated with CIN classification(r=0.711,0.683,0.704,P<0.05)in CIN patients.ROC curve analysis showed that the area under the curve of serum sTNFR-Ⅰ,CEACAM6 and BK in the diagnosis of CIN and cervical cancer was 0.926 and 0.922 respectively.The results of ri

关 键 词：可溶性肿瘤坏死因子受体Ⅰ 癌胚抗原相关细胞黏附分子6 缓激肽 宫颈上皮内瘤变 宫颈癌 诊断价值 

分 类 号：R711.32[医药卫生—妇产科学] R446.1[医药卫生—临床医学]