血清sdLDL-C、MFG-E8、LRG1联合检测对糖尿病早期肾损伤的诊断价值  

Diagnostic value of combined detection of serum sdLDL-C,MFG-E8 and LRG1 in early diabetic kidney injury

作　　者：姚林 刘连庚 杨漫 冒小红 YAO Lin;LIU Liangeng;YANG Man;MAO Xiaohong(Department of Laboratory Medicine,Yancheng Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine,Yancheng,Jiangsu 224001,China)

机构地区：[1]南京中医药大学附属盐城中医院检验科,江苏盐城224001

出　　处：《检验医学与临床》2025年第5期678-682,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨血清小而密低密度脂蛋白胆固醇(sdLDL-C)、乳脂球表皮生长因子8(MFG-E8)、富亮氨酸α2糖蛋白1(LRG1)联合检测对糖尿病早期肾损伤的诊断价值。方法选取2021年11月至2023年11月在该院治疗的90例糖尿病早期肾损伤患者作为观察组,另选取同期在该院治疗的90例单纯糖尿病患者作为对照组。比较观察组和对照组临床资料、尿酸(UA)、尿素、血清肌酐(SCr)、尿微量清蛋白/尿肌酐比值(UACR),以及血清sdLDL-C、MFG-E8、LRG1水平。采用Pearson相关分析糖尿病早期肾损伤患者血清sdLDL-C、MFG-E8、LRG1水平与SCr、尿素、UA水平及UACR的相关性。采用多因素Logistic回归分析糖尿病患者发生早期肾损伤的影响因素。采用受试者工作特征(ROC)曲线分析血清sdLDL-C、MFG-E8、LRG1对糖尿病患者发生早期肾损伤的诊断价值。结果观察组和对照组糖尿病病程、贫血占比和UACR,以及血清SCr、尿素、UA、sdLDL-C、LRG1、MFG-E8水平比较,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,糖尿病早期肾损伤患者血清sdLDL-C、LRG1水平与SCr、尿素、UA水平及UACR均呈正相关(P<0.05),MFG-E8水平与SCr、尿素、UA水平及UACR均呈负相关(P<0.05)。多因素Logistic回归分析结果显示,sdLDL-C、MFG-E8、LRG1、尿素、UA、UACR均为糖尿病患者发生早期肾损伤的影响因素(P<0.05)。ROC曲线分析结果显示,血清sdLDL-C、MFG-E8、LRG1联合检测诊断糖尿病患者发生早期肾损伤的曲线下面积(AUC)为0.912,大于3项指标单独检测的0.857、0.801、0.834,差异均有统计学意义(Z=2.099、3.147、2.630,P=0.036、0.002、0.009)。结论糖尿病早期肾损伤患者血清sdLDL-C、LRG1水平均升高,MFG-E8水平降低,且sdLDL-C、MFG-E8、LRG1均为糖尿病患者发生早期肾损伤的影响因素,3项指标联合检测对糖尿病患者发生早期肾损伤具有更高的诊断价值。Objective To investigate the diagnostic value of combined detection of serum small dense low-density lipoprotein cholesterol(sdLDL-C),milk fat globule epidermal growth factor 8(MFG-E8)and leucine-richα2-glycoprotein 1(LRG1)in early diabetic kidney injury.Methods A total of 90 patients with early diabetic kidney injury treated in the hospital from November 2021 to November 2023 were selected as the observation group,and 90 patients with simple diabetes treated in the hospital during the same period were selected as the control group.The clinical data,uric acid(UA),urea,serum creatinine(SCr),urine microalbumin/creatinine ratio(UACR),and serum sdLDL-C,MFG-E8,LRG1 levels were compared between the observation group and the control group.Pearson correlation analysis was used to analyze the correlation of serum sdLDL-C,MFG-E8,LRG1 levels with SCr,urea,UA levels and UACR in patients with early diabetic kidney injury.Multivariate Logistic regression was used to analyze the influencing factors of early renal injury in diabetic patients.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum sdLDL-C,MFG-E8 and LRG1 for early renal injury in diabetic patients.Results There were statistically significant differences in the course of diabetes,the proportion of anemia,UACR,and serum SCr,urea,UA,sdLDL-C,LRG1 and MFG-E8 levels between the observation group and the control group(P<0.05).Pearson correlation analysis showed that serum sdLDL-C and LRG1 levels in patients with early diabetic kidney injury were positively correlated with SCr,urea,UA levels and UACR(P<0.05).The level of MFG-E8 was negatively correlated with SCr,urea,UA and UACR(P<0.05).Multivariate Logistic regression analysis showed that sdLDL-C,MFG-E8,LRG1,urea,UA and UACR were all influencing factors for early renal injury in diabetic patients(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of combined detection of serum sdLDL-C,MFG-E8 and LRG1 in the diagnosis of early renal injury in diabetic patients was 0

关 键 词：糖尿病早期肾损伤 小而密低密度脂蛋白胆固醇 乳脂球表皮生长因子 富亮氨酸α2糖蛋白1 诊断价值 

分 类 号：R587.1[医药卫生—内分泌] R446.1[医药卫生—内科学]