沙库巴曲缬沙坦联合酒石酸美托洛尔治疗高血压伴心力衰竭的疗效及其对血压及心功能指标的影响  

Efficacy of sacubitril valsartan combined with metoprolol tartrate in the treatment of hypertension with heart failure and its effect on blood pressure and cardiac function indexes

作　　者：谢勇 徐祖余 胡海强 江怡 XIE Yong;XU Zuyu;HU Haiqiang;JIANG Yi(Department of Cardiology,Xinyu Beihu Hospital,Xinyu,Jiangxi 338000,China;Department of Critical Care Medicine,Xinyu People′s Hospital,Xinyu,Jiangxi 338000,China;Department of Critical Care Medicine,Xinyu Beihu Hospital,Xinyu,Jiangxi 338000,China;Department of Critical Care Medicine,Xinyu Hospital of Traditional Chinese Medicine,Xinyu,Jiangxi 338000,China)

机构地区：[1]江西省新余北湖医院心血管内科,江西新余338000 [2]江西省新余市人民医院重症医学科,江西新余338000 [3]江西省新余北湖医院重症医学科,江西新余338000 [4]江西省新余市中医院重症医学科,江西新余338000

出　　处：《检验医学与临床》2025年第5期695-698,共4页Laboratory Medicine and Clinic

基　　金：江西省新余市科技计划项目(20223091007)。

摘　　要：目的探讨沙库巴曲缬沙坦与酒石酸美托洛尔联合应用对高血压伴心力衰竭的临床疗效及其对血压及心功能指标的影响。方法选取2022年4月至2023年5月江西省新余北湖医院收治的100例高血压伴心力衰竭患者作为研究对象,按照随机数字表法分为对照组和观察组,每组50例。对照组采用酒石酸美托洛尔治疗,观察组在对照组基础上联合沙库巴曲缬沙坦治疗,2组均连续治疗4周。比较2组临床疗效、心功能指标水平、血压及不良反应。结果观察组总有效率为96.00%,高于对照组的82.00%(P<0.05)。2组治疗前心功能指标水平及血压比较均无差异(P>0.05);2组治疗后左室射血分数(LVEF)均较治疗前高,且观察组治疗后LVEF均较对照组高(P<0.05);2组治疗后左心室收缩末期内径(LVESD)、心率(HR)、左心室舒张末期内径(LVEDD)、舒张压、收缩压均较治疗前低,且观察组治疗后LVESD、HR、LVEDD、舒张压、收缩压均较对照组低(P<0.05)。2组不良反应比较无差异(P>0.05)。结论沙库巴曲缬沙坦联合酒石酸美托洛尔治疗可以降低高血压伴心力衰竭患者的血压,改善其心功能,临床疗效明显,且安全可靠。Objective To investigate the clinical efficacy of sacubitril valsartan combined with metoprolol tartrate in the treatment of hypertension with heart failure and its effect on blood pressure and cardiac function.Methods A total of 100 patients with hypertension and heart failure admitted to Xinyu Beihu Hospital of Jiangxi Province from April 2022 to May 2023 were selected as the research objects.According to the random number table method,they were divided into control group and observation group,with 50 cases in each group.The control group was treated with metoprolol tartrate,and the observation group was treated with sacubitril valsartan on the basis of the control group.Both groups were treated for 4 weeks.The clinical efficacy,cardiac function index levels,blood pressure and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 96.00%,which was higher than 82.00%of the control group(P<0.05).There was no significant difference in cardiac function and blood pressure between the two groups before treatment(P>0.05).After treatment,the left ventricular ejection fraction(LVEF)of the two groups was higher than that before treatment,and the observation group was higher than the control group(P<0.05).After treatment,the left ventricular end-systolic diameter(LVESD),heart rate(HR),left ventricular end-diastolic diameter(LVEDD),diastolic blood pressure and systolic blood pressure in the two groups were lower than those before treatment,and LVESD,HR,LVEDD,diastolic blood pressure and systolic blood pressure in the observation group after treatment were lower than those in the control g roup(P<0.05).There was no significant difference in adverse reactions between the two group s(P>0.05).Conclusion Sacubitril valsartan combined with metoprolol tartrate can reduce blood pressure level and improve cardiac function in patients with hypertension and heart failure,with obvious clinical efficacy,safety and reliability.

关 键 词：高血压 心力衰竭 沙库巴曲缬沙坦 酒石酸美托洛尔 疗效 心功能 

分 类 号：R544.1[医药卫生—心血管疾病] R541.6[医药卫生—内科学] R446.1[医药卫生—临床医学]