吡嗪稠合共价有机框架的构建与电化学检测磺胺甲唑  

Construction of Pyrazine-Fused Covalent Organic Framework and Their Electrochemical Detection of Sulfamethoxazole

作　　者：年恩赐 巩舜忠 姜珊 李承乾 陈人杰 陶娆 张毅 刘空 鞠海东 NIAN Enci;GONG Shunzhong;JIANG Shan;LI Chengqian;CHEN Renjie;TAO Rao;ZHANG Yi;LIU Kong;JU Haidong(School of Chemisty and Chemical Engineering,Kunming University,Kunming 650214,China)

机构地区：[1]昆明学院化学化工学院,云南昆明650214

出　　处：《云南化工》2025年第2期26-31,共6页Yunnan Chemical Technology

基　　金：昆明学院引进人才项目(YJL23019,YJL22014);教育厅研究生类项目(2024Y760);国家自然科学基金地区项目(2216050208);云南省地方本科高校基础研究联合专项项目(Grant202301 BA070001-128)。

摘　　要：以共价有机框架(COF)为电化学传感器,用于磺胺甲(口恶)唑(SMX)的检测。以环己六酮八水合物和1,2,4,5-苯四胺四盐酸盐为前体,用溶剂热方式合成了全共轭吡嗪环连接的共价有机框架材料(标记为Hex-Aza-COF)。采用扫描电镜、傅里叶变换光谱、X射线衍射等对材料的形貌和结构进行了表征。将Hex-Aza-COF与玻碳电极制成电化学传感器,采用一系列电化学分析手段检测了5种抗生素。由于Hex-Aza-COF具有丰富的孔道结构及吡嗪类稠环体系的氧化还原活性,该Hex-Aza-COF传感器对SMX具有良好的信号响应。通过差分脉冲伏安法(DPV)实验表明,该Hex-Aza-COF传感器对SMX具有较低的检测限(0.176μmol/L),并具有良好的选择性和灵敏度。Covalent organic frame(COF)was used as an electrochemical sensor for the detection of sulfamethoxazole(SMX).Covalent organic frame material with fully conjugated pyrazine ring link(labeled with Hex-Aza-COF)was synthesized with 1,2,4,5-phenytetramine tetra-hydro-chloride as precursors.The morphology and structure of the materials were characterized by SEM,Fourier transform spectroscopy,and X-ray dif-fraction.An electrochemical sensor made of Hex-Aza-COF with a glass carbon electrode detected five antibiotics using a series of electrochemical analysis methods.Due to the Hex-Aza-COF rich pore structure and of the redox activity of the pyrazine-like thick ring system,the Hex-Aza-COF sensor has a good signaling response to SMX.The differential pulse voltammetry(DPV)experiment shows that the Hex-Aza-COF sensor has a low detection limit(0.176μmol/L),with good selectivity and sensitivity.

关 键 词：吡嗪稠合共价有机框架 π-共轭材料 电化学分析检测 抗生素 差分脉冲伏安法 溶剂热合成法 

分 类 号：O657[理学—分析化学] TS207[理学—化学]