超分子溶剂应用于药物中尼泊金酯类物质的含量测定  

Determination of Nipaginesters in Drugs Using Supramolecular Solvents

作　　者：江小舟 刘汗青 高树林 翁哲慧 JIANG Xiaozhou;LIU Hanqing;GAO Shulin;WENG Zhehui(School of Chemistry and Chemical Engineering,Kunming University,Kunming 650214,China;Ruili Customs Comprehensive Technology Center,Ruili 678699,China)

机构地区：[1]昆明学院化学化工学院,云南昆明650214 [2]瑞丽海关综合技术中心,云南瑞丽678699

出　　处：《云南化工》2025年第2期65-69,共5页Yunnan Chemical Technology

基　　金：国家自然科学基金(22066014)。

摘　　要：开发了一种基于超分子溶剂体系的新型涡旋辅助-分散液液微萃取方法,结合高效液相色谱技术用于检测尼泊金酯类物质。针对传统方法中四氢呋喃的使用不符合绿色化学原则及操作复杂的问题,构建了六氟丁醇和癸醇超分子溶剂体系。六氟丁醇充当氢键供体与密度调节剂促进超分子结构形成,增强萃取效果。通过优化诱导剂用量、两亲性物质含量、涡旋时间、pH值及盐浓度等关键参数,确立最佳萃取条件:六氟丁醇用量4.8%,两亲性物质用量3%,涡旋时间30 s,溶液pH值为7,盐质量分数1%。在此条件下,方法具有良好的线性关系,相对标准偏差为1.6%~4.7%,检出限为0.8~1.5 ng/mL,定量限为2.8~10 ng/mL。研究结果表明方法流程简便、环保,符合绿色化学要求,为尼泊金酯类物质相关分析检测提供了参考和借鉴。A novel vortex assisted liquid-liquid microextraction method based on supramolecular solvent system was developed,combined with high-performance liquid chromatography technology for the detection of nipagin esters.In response to the problem that the use of tetrahydrofuran in traditional methods does not comply with green chemistry principles and is complex to operate,this study constructed a supramolecular solvent system of hexafluorobutanol and decanol.Hexafluorobutanol acts as a hydrogen bond donor and density regulator to promote the formation of su-pramolecular structures and enhance extraction efficiency.By optimizing key parameters such as inducer dosage,amphiphilic substance content,vortex time,pH value,and salt concentration,the optimal extraction conditions were established:hexafluorobutanol dosage of 4.8%,amphiphilic substance dosage of 3%,vortex time of 30 seconds,solution pH value of 7,and salt concentration of 1%.Under these conditions,the method has a good linear relationship with a relative standard deviation of 1.6%-4.7%,a detection limit of 0.8-1.5 ng/mL,and a quantification limit of 2.8-10 ng/mL.This method has a simple and environmentally friendly process,meets the requirements of green chemistry,and provides a new tool for analytical chemistry.

关 键 词：六氟丁醇 超分子溶剂 涡旋辅助-分散液液微萃取 尼泊金酯 高效液相色谱 

分 类 号：TQ413[化学工程] O657[理学—分析化学]