基于自噬探讨针刺改善缺血性脑卒中的机制研究进展  

Research progress on the mechanisms of acupuncture in improving ischemic stroke through autophagy

作　　者：王宇[1] 代一宁 郭孝静 花淼 张立[1,2] WANG Yu;DAI Yi-ning;GUO Xiao-jing;HUA Miao;ZHANG Li(Heilongjiang University of Chinese Medicine,Harbin 150040,China;The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150001)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第二医院,哈尔滨150001

出　　处：《针刺研究》2025年第2期204-209,共6页Acupuncture Research

基　　金：哈尔滨市科技计划自筹经费项目(No.2022ZCZJNS070)。

摘　　要：脑卒中是全球发病率、致残率、死亡率均较高的疾病。近年来,大量研究证实针刺治疗缺血性脑卒中与调节自噬密切相关。本文通过总结近年来的文献,分别从针刺对自噬体介导的降解途径、自噬相关蛋白表达、自噬相关通路、线粒体自噬的影响等方面进行论述,并进一步探讨针刺调控自噬改善缺血性脑卒中的机制,为临床治疗提供新思路和方案。Stroke is a major disease with high incidence,disability rate,and mortality worldwide.In recent years,a large number of studies have comfirmed that acupuncture treatment for ischemic stroke is closely related to the regulation of autophagy mechanisms.This article summarizes the literature in recent years,discusses the effects of acupuncture on the degradation pathways mediated by autophagosomes,the expression of autophagy-related proteins,autophagy-related pathways,and the impact of mitophagy,and further explores the mechanisms of acupuncture in regulating autophagy to improve ischemic stroke,providing new ideas and schemes for clinical treatment.

关 键 词：缺血性脑卒中 针刺 自噬 机制 综述 

分 类 号：R246.6[医药卫生—针灸推拿学]