基于针刺调节程序性细胞死亡探讨其脑保护作用  

Cerebral protective effect of acupuncture based on its regulative effect on programmed cell death

作　　者：苑功名 苏枫雅 李佩云 郭永明[1,2,3,4] 张健 徐媛 吕中茜[1,2,3,4] 赵季宇 公一囡[1,2,3,4] YUAN Gong-ming;SU Feng-ya;LI Pei-yun;GUO Yong-ming;ZHANG Jian;XU Yuan;LÜZhong-xi;ZHAO Ji-yu;GONG Yi-nan(Research Center of Experimental Acupuncture Science,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;School of Acupuncture-Moxibustion and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 301617;Tianjin Key Laboratory of Modern Chinese Medicine Theory Innovation and Transformation,Tianjin 301617;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 301617;Shanghai Key Laboratory of New Drug Design&Modern Engineering Center for Traditional Chinese Medicine,School of Pharmacy,East China University of Science and Technology,Shanghai 200237)

机构地区：[1]天津中医药大学实验针灸学研究中心,天津301617 [2]天津中医药大学针灸推拿学院,天津301617 [3]天津市现代中医理论创新转化重点实验室,天津301617 [4]国家针灸临床医学研究中心,天津301617 [5]华东理工大学药学院上海新药设计重点实验室,上海200237

出　　处：《针刺研究》2025年第2期210-216,共7页Acupuncture Research

基　　金：国家自然科学基金项目(No.82205279、82274649);中华中医药学会青年人才托举工程项目(No.2023-QNRC2-B04)。

摘　　要：大脑内的程序性细胞死亡(PCD)贯穿生命全过程,异常PCD可能是导致脑病的重要因素。本文围绕针刺对PCD的影响,从传统中医学角度总结了针刺产生脑保护作用的理论基础及多靶点、双向、整体调节等治疗特点;从现代医学角度对针刺调节细胞凋亡、自噬、焦亡、铁死亡、坏死性凋亡等方面进行了梳理,探讨针刺基于PCD恢复或重塑受损脑功能,改善脑病的作用机制。Programmed cell death(PCD)in the brain occurs throughout the whole process of life,and abnormal PCD may be an important factor leading to encephalopathy.It has been demonstrated that acupuncture has a good cerebral protective effect in the treatment of epilepsy,Alzheimer’s disease,Parkinson’s disease,depression,anxiety,insomnia,migraine and other dozens of brain diseases,and possesses characteristics of multi-point,networking,two-way and holistic regulation.In the present paper,we sum up the protective effect of acupuncture therapy from 1)cell apoptosis(for example,improving post-surgery cognition impairment,traumatic brain injury and ischemic stroke by relieving mitochondrial damage,activating mitochondrial autophagy,increasing blood-brain barrier permeability,and thus reducing cell apoptosis),2)cell autophagy(for example,improving post-surgery cognition impairment,traumatic brain injury and ischemic stroke by relieving mitochondrial damage,activating mitochondrial autophagy,and increasing blood-brain barrier permeability,and thus reducing cell apoptosis),3)pyroptosis(for example,inhibiting abnormally-activated inflammasomes,and caspase and gasdermin D activity to remit pyroptosis in the treatment of stroke,depression,Parkinson’s disease,and Alzheimer’s disease animal models),4)ferroptosis(for instance,regulating iron ion metabolism,relieving lipid peroxidation damage,and thus playing a brain protection role in the treatment of ischemic and hemorrhagic stroke animal models),5)necroptosis(inhibiting necrotic apoptosis mediated by receptor-interacting protein kinase 1 in intracerebral hemorrhage rats),and so on.We believe that along with the continuous development of brain science,artificial intelligence,big data and other new concepts and new technologies,it is expected to expand and improve the research level and quality of acupuncture in the prevention and treatment of encephalopathy through faster,more accurate and more comprehensive methods,which will help promote the modern interpretation of the brai

关 键 词：针刺 脑病 程序性细胞死亡 脑保护作用 

分 类 号：R245[医药卫生—针灸推拿学]