针刺治疗哮喘的临床及机制研究进展  

Progress on clinical and mechanism researches of acupuncture therapy for asthma

作　　者：王婷婷 宋桂华[1,2] WANG Ting-ting;SONG Gui-hua(School of Pediatrics,Henan University of Chinese Medicine,Zhengzhou 450000,China;Department of Pediatrics,The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000)

机构地区：[1]河南中医药大学儿科医学院,郑州450000 [2]河南中医药大学第一附属医院儿科,郑州450000

出　　处：《针刺研究》2025年第2期217-223,共7页Acupuncture Research

基　　金：国家自然科学基金项目(No.81873338);河南省中医药学科领军人才培养项目(No.豫卫中医函[2021]8号)。

摘　　要：哮喘是一种反复发作、难以根治的慢性肺系疾病。临床研究表明针刺可有效缓解哮喘相关症状,是治疗哮喘的理想手段。本文对近5年国内外针刺治疗哮喘的临床和机制研究进行综述,为今后开展哮喘相关研究提供依据。结果显示,针刺治疗哮喘的作用机制可能与调控免疫细胞因子,改善铁代谢紊乱,调节神经递质与受体表达,促进嗜酸性粒细胞凋亡,抑制基质金属蛋白酶-9及基质金属蛋白酶抑制剂-1表达,抑制2型固有淋巴样细胞相关蛋白及基因表达,抑制转化生长因子β1/Smad、丝裂原活化蛋白激酶、磷脂酰肌醇3-激酶/蛋白激酶B、信号转导和转录启动因子及核因子-κB等信号通路有关,从而抑制气道炎性反应、减轻气道高反应、缓解气道重塑。Asthma is a chronic lung disease that occurs repeatedly and is hardly cured.Clinical studies have shown that acupuncture can effectively relieve asthma-related symptoms and is an ideal measure to treat asthma.The paper reviews the clinical and mechanism researches of acupuncture for asthma reported in China and other countries in recent 5 years,so as to provide the relevant evidences for the further study on asthma.The results showed that the mechanism of acupuncture in treatment of asthma may be related to modulating immune cytokines,ameliorating iron metabolism disorder,regulating the expression of neurotransmitter and receptor,promoting eosinophile apoptosis,inhibiting the expression of matrix metalloproteinase-9 and matrix metalloproteinase inhibitor-1,suppressing the expression of the related proteins and genes in type 2 innate lymphoid cells,inhibiting the signal pathways such as transforming growth factor-β1/Smad,mitogen-activated protein kinase,phosphatidylinositol 3-kinase/protein kinase B,signal transducer and activator of transcription,and nuclear factor-κB.Accordingly,the airway inflammatory response can be suppressed,the airway hyperreactivity be reduced,and the airway remodeling be relieved.

关 键 词：哮喘 针刺 临床研究 机制研究 

分 类 号：R246.1[医药卫生—针灸推拿学]