瘢痕疙瘩诊疗的相关研究进展  

Recent Advances in the Diagnosis and Treatment of Keloids

作　　者：盛泓锦 张连波[1] SHENG Hongjin;ZHANG Lianbo(Department of Plastic Surgery,China-Japan Union Hospital of Jilin University,Changchun,Jilin Province 130033,China)

机构地区：[1]吉林大学中日联谊医院整形外科,吉林长春130033

出　　处：《中国实验诊断学》2025年第2期240-244,共5页Chinese Journal of Laboratory Diagnosis

摘　　要：瘢痕疙瘩是一种常见的皮肤疾病,其核心在于细胞外基质的异常积累和纤维组织的过度增殖。其诊断主要依据患者的病史描述及临床表现,如疼痛、瘙痒、皮肤硬结及病变向周围正常皮肤侵犯等典型症状。此外,组织活检也是常用的诊断手段之一。目前的治疗手段主要包括药物治疗和手术治疗,例如局部类固醇注射和手术切除,但瘢痕疙瘩的复发率仍然居高不下。由于瘢痕疙瘩形成的病理机制尚未明确阐明,并缺乏特异的诊断标志物及安全、精准和有效的分子治疗靶点,本文从疾病预测和临床诊断两个方面总结瘢痕疙瘩的诊断及预测标志物,并总结分析瘢痕疙瘩发病机制及治疗措施的最新进展。Keloid is a common skin disease,with its core issue being the abnormal accumulation of extracellular ma-trix and excessive proliferation of fibrous tissue.Its diagnosis mainly relies on the patient's medical history and clinical manifestations,such as pain,itching,skin induration,and the lesion's invasion into the surrounding normal skin.Addi-tionally,tissue biopsy is also a commonly used diagnostic method.Current treatment options mainly include drug thera-py and surgical treatment,such as local steroid injections and surgical excision.However,the recurrence rate of keloid remains high.Due to the unclear pathological mechanism of keloid formation and the lack of specific diagnostic markers and safe,precise,and effective molecular therapeutic targets,this article summarizes the diagnostic and predictive mark-ers of keloid from the aspects of disease prediction and clinical diagnosis,and reviews the latest progress in the patho-genesis and treatment measures of keloid.

关 键 词：瘢痕疙瘩 发病机制 诊断标志物 新型治疗 

分 类 号：R622[医药卫生—整形外科]