局部麻醉剂苯佐卡因教学实验创新性改进设计  

Innovative and Improved Design for the Preparation of Local Anesthetic Benzocaine

作　　者：孟令国[1] 蒋越 段荣琛 苏玉洁 张金凤 MENG Lingguo;JIANG Yue;DUAN Rongchen;SU Yujie;ZHANG Jinfeng(School of Chemistry and Material Science,Huaibei Normal University,235000,Huaibei,Anhui,China)

机构地区：[1]淮北师范大学化学与材料科学学院,安徽淮北235000

出　　处：《淮北师范大学学报(自然科学版)》2025年第1期88-91,共4页Journal of Huaibei Normal University:Natural Sciences

基　　金：安徽省质量工程项目(2022zygzts099,2023jyxm0503);淮北师范大学质量工程项目(2020xjxyj017,2023jxyj032);淮北师范大学自然科学结余经费项目(2023ZK078,2023ZK079)。

摘　　要：为解决传统实验教学多步反应制备局部麻醉剂苯佐卡因(对氨基苯甲酸乙酯)存在使用腐蚀性强酸带来的安全隐患和“三废”问题,利用电化学合成策略对其进行创新改进。改进实验不仅实现合成的高效性、经济性、绿色环保性,而且根植绿色合成理念,提升学生创新能力,促进提高化学人才培养质量。To solve the safety hazards and“three wastes”problems caused by the use of corrosive strong acid in the preparation of local anesthetic benzocaine(ethyl para-aminobenzoate)by multi-step reaction in traditional experimental teaching,the electronchemical synthesis strategy was incorporated to achieve the innovation and improvement of this experiment.The improved experiments not only achieve synthetic efficiency,economy and green environmental protection,but also root in the concept of green synthesis,enhance the innovative ability of students,and promote the improvement of the quality of training chemical talents.

关 键 词：苯佐卡因 电化学 绿色合成 改进实验设计 

分 类 号：O621.3[理学—有机化学]