促炎性细胞因子对儿童烧伤脓毒症早期诊断的有效分析  

Effective analysis of proinflammatory cytokines in early diagnosis of burn sepsis in children

作　　者：吕臣 汤紫文 安思远 宋巧玲 康生军 栾志勇 Lv Chen;Tang Ziwen;An Siyuan;Song Qiaoling;Kang Shengjun;Luan Zhiyong(Changchun University of Traditional Chinese Medicine,Changchun Jilin,130000,China;The First Affiliated Hospital of Nanchang University,Nanchang Jiangxi,330000,China)

机构地区：[1]长春中医药大学,吉林长春130000 [2]南昌大学第一附属医院,江西南昌330000

出　　处：《中外女性健康研究》2025年第2期26-28,32,共4页Women's Health Research

摘　　要：目的:回顾研究儿童烧伤脓毒症早期阶段的静脉血中促炎性细胞因子IL-2、IL-1β、TNF-α、IL-6和IL-8的表达水平,探究其在疾病早期诊断等方面的临床应用价值。方法:在本研究中,对2020年1月至2023年12月本院所有烧伤患儿应用随机抽样法选取30例普通烧伤儿童作为对照组,同时观察同期30例因烧伤导致脓毒症的儿童作为观察组。本研究对比分析了这两组患者的静脉血促炎性细胞因子,对P<0.05的检测指标进行二元logistic回归分析。此外,本研究还绘制了受试者工作特征曲线(ROC曲线),以分析烧伤导致脓毒症相关的指标的诊断效能。结果:相较于对照组,观察组的IL-1β、TNF-α、IL-6和IL-8水平显著提高(P<0.05)。IL-6、IL-1β、IL-8水平与烧伤患儿是否并发脓毒症呈显著正向相关性(P<0.05)。IL-6、IL-1β、IL-8的ROC曲线下面积(AUC)分别为0.7728、0.7661、0.7456。IL-6与IL-8的联合检测、IL-6与IL-1β的联合检测、IL-1β与IL-8的联合检测以及三项指标联合检测的ROC曲线下面积分别达到0.8378、0.8256、0.7872和0.8576。在这些检测方法中,三项联合检测的准确率和特异度最高,而IL-6与IL-1β联合检测的灵敏度则位居首位。结论:促炎性细胞因子IL-1β、IL-6和IL-8的表达水平对儿童烧伤脓毒症的早期诊断具有一定作用,联合检测特别是三项联合检测的早期诊断效率更优异并且能够以此提供患儿早期发现并治疗脓毒症的临床依据。Objective:To review and study the expression levels of proinflammatory cytokines IL-2,IL-1β,TNF-α,IL-6 and IL-8 in the venous blood of children with burn sepsis in the early stage,and to explore their clinical application value in aspects such as early disease diagnosis.Methods:In this study,from January 2020 to December 2023,30 children with ordinary burns were selected as the control group by random sampling from all burned children in our hospital.Meanwhile,30 children who developed sepsis due to burns during the same period were observed as the observation group.This study compared and analyzed the proinflammatory cytokines in the venous blood of the two groups of patients and performed a binary logistic regression analysis on the detection indexes with P<0.05.In addition,this study also drew the receiver operating characteristic curve(ROC curve)to analyze the diagnostic efficacy of the indexes related to sepsis caused by burns.Results:Compared with control group,the levels of IL-1β,TNF-α,IL-6 and IL-8 in observation group were significantly increased(P<0.05).IL-6,IL-1βand IL-8 levels were significantly positively correlated with sepsis in burn children(P<0.05).The area under ROC curve(AUC)of IL-6,IL-1βand IL-8 were 0.7728,0.7661 and 0.7456,respectively.Combined detection of IL-6 and IL-8;Combined detection of IL-6 and IL-1β;The area under ROC curve of the combined detection of IL-1βand IL-8 and the combined detection of the three indexes reached 0.8378,0.8256,0.7872 and 0.8576,respectively.Among these methods,the accuracy and specificity of the three combined tests were the highest,while the sensitivity of the combined detection of IL-6 and IL-1βwas the first.Conclusion:The expression levels of proinflammatory cytokines IL-1β,IL-6 and IL-8 play a certain role in the early diagnosis of burn sepsis in children.It was first proposed that the combined detection,especially the three combined detection,has better early diagnosis efficiency and can provide clinical basis for early detection and treatment

关 键 词：儿童烧伤 脓毒症 细胞因子 

分 类 号：R725[医药卫生—儿科]