基于不同预测标志物建立的妊娠糖尿病预测模型研究进展  

Research progress on the prediction models of gestational diabetes mellitus based on different predictive biomarkers

作　　者：多妍蓓 赵维纲 Duo Yanbei;Zhao Weigang(Department of Endocrinology,Key Laboratory of Endocrinology of National Health Commission,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院、北京协和医学院、北京协和医院内分泌科、国家卫生健康委员会内分泌重点实验室,北京100730

出　　处：《中华临床营养杂志》2025年第1期54-64,共11页Chinese Journal of Clinical Nutrition

摘　　要：妊娠糖尿病(gestational diabetes mellitus,GDM)是妊娠常见并发症之一,可影响母婴妊娠期间及产后长期的糖代谢状况,并与多种围产期并发症密切相关。为能尽早预判GDM的发生,近年来许多研究致力于探索GDM的早期预测标志物,并应用临床指标、生化标志物、代谢/蛋白质组学标志物、基因多态性等指标建立了多种GDM早期预测模型。本文检索了目前已发表的GDM预测模型相关文献,从研究类型、建模方法、应用指标、模型预测能力、验证情况等多个角度进行汇总和评价,为GDM的早期防控提供指导。Gestational diabetes mellitus(GDM)is one of the most common complications of pregnancy,which affects maternal and infantile glucose metabolism both during pregnancy and in the long-term postpartum and is closely related to several perinatal complications.In recent years,many studies devote to exploring early predictive biomarkers of GDM,and a variety of early prediction models of GDM have been established using clinical indicators,biochemical markers,metabolic/proteomic markers,gene polymorphisms,etc.This review summaries and evaluates the published GDM prediction models in terms of research types,modeling methods,indicators,model prediction performance,and validation,attempting to inform the early prevention of GDM.

关 键 词：妊娠糖尿病 预测模型 预测标志物 早期预测 

分 类 号：R71[医药卫生—妇产科学]