红细胞膜伪装的仿生纳米递送系统在疾病治疗中的应用  

Biomimetic nanoparticle delivery systems b ased on red blood cell membranes for disease treatment

作　　者：高晨霞 肖艳余 陈雨雪源 任晓亮[1] 陈美玲 GAO Chen-xia;XIAO Yan-yu;CHEN Yu-xue-yuan;REN Xiao-liang;CHEN Mei-ling(School of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学中药学院,天津301617

出　　处：《药学学报》2025年第2期348-358,共11页Acta Pharmaceutica Sinica

基　　金：天津市科技计划项目(21JCQNJC01350);天津中医药大学中药学院科研支持基金项目(ZR19)。

摘　　要：纳米递送系统在精准治疗领域具有良好的应用前景,但纳米材料在制备过程中存在体内循环时间较短,易被机体内免疫系统识别、清除等问题。近年来为解决这些问题,由天然细胞膜介导的仿生纳米递送系统已成为研究热点。天然膜仿生递送系统使用机体内源性细胞膜对纳米载体表面进行包覆修饰,巧妙地将天然生物膜“自体”性质和“人工”功能载体的优势相融合,赋予其肿瘤靶向性、低免疫原性和血液长循环等特点。目前仿生纳米递送系统已用于治疗恶性肿瘤、心血管疾病、细菌感染等多种疾病。本文对天然细胞膜伪装的仿生纳米递送系统的发展状况与当前的研究热点进行分析,综述了近年来红细胞膜伪装的仿生纳米递送系统在疾病治疗领域的最新研究进展,重点探讨基于红细胞膜伪装的仿生纳米递送系统在改善药物递送方面的优势作用,未来发展前景及局限性,以期为该系统的深入研究与开发提供参考。Nanoparticle delivery systems have good application prospects in the field of precision therapy,but the preparation process of nanomaterial has problems such as short in vivo circulation time,easy recognition,and clearance by the immune system in the body.In recent years,biomimetic nanoparticle delivery systems mediated by natural cell membranes have become a research hotspot to address these issues.The natural membrane biomimetic nanoparticle delivery system cleverly integrates the advantages of natural biofilm"autologous"and"artificial"functional carriers by using endogenous cell membranes to modify the surface of nanocarriers,endowing them with characteristics such as tumor targeting,low immunogenicity,and long blood circulation.Currently,biomimetic nanoparticle delivery systems have been used in the treatment of malignant tumors,cardiovascular diseases,bacterial infections,and other diseases.This paper analyzes the development status and current research hotspots of natural cell membrane camouflaged biomimetic nanoparticle delivery systems mainly reviews the latest research progress of red blood cell membrane camouflaged biomimetic nanoparticle delivery systems in the field of disease treatment in recent years.It focuses on exploring the advantages,future development prospects,and limitations of biomimetic nanoparticle delivery systems based on red blood cell membrane camouflage in improving drug delivery,to provide a reference for the in-depth research and development of this system.

关 键 词：红细胞膜 仿生 纳米递送系统 肿瘤 

分 类 号：R943[医药卫生—药剂学]