木鳖子仁中5个新的三萜皂苷类成分  

Five new triterpenoid saponins from the kernels of Momordica cochinchinensis

作　　者：丁如 王嘉祺 罗翌玚 韩永龙[2] 李晓波[1] 王梦月[1] DING Ru;WANG Jia-qi;LUO Yi-yang;HAN Yong-long;LI Xiao-bo;WANG Meng-yue(School of Pharmaceutical Science,Shanghai Jiao Tong University,Shanghai 200240,China;Department of Pharmacy,Shanghai Sixth People's Hospital,Shanghai 200233,China)

机构地区：[1]上海交通大学药学院,上海200240 [2]上海市第六人民医院药剂科,上海200233

出　　处：《药学学报》2025年第2期442-448,共7页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金(82274061);内蒙古自治区“科技兴蒙”计划(2022XYJG0001-02-01)。

摘　　要：采用大孔树脂、硅胶、ODS柱层析、半制备HPLC等色谱技术,从木鳖子种仁中分离了5个皂苷类成分;利用HR-MS、NMR技术,结合碱水解、酸水解方法,鉴定为:丝石竹皂苷元-3-O-{β-D-吡喃半乳糖基(1→2)-[α-L-吡喃鼠李糖基(1→3)]-β-D-吡喃葡萄糖醛酸基}-28-O-β-D-吡喃木糖基(1→3)-[β-D-吡喃木糖基(1→4)]-α-L-吡喃鼠李糖基(1→2)-β-D-吡喃岩藻糖苷(1)、皂皮酸-3-O-{β-D-吡喃半乳糖基(1→2)-[α-L-吡喃鼠李糖基(1→3)]-β-D-吡喃葡萄糖醛酸基}-28-O-β-D-吡喃木糖基(1→3)-[β-D-吡喃木糖基(1→4)]-α-L-吡喃鼠李糖基(1→2)-β-D-吡喃岩藻糖苷(2)、丝石竹皂苷元-3-O-β-D-吡喃半乳糖基(1→2)-[α-L-吡喃鼠李糖基(1→3)]-β-D-吡喃葡萄糖醛酸苷钠(3)、皂皮酸-3-O-β-D-吡喃半乳糖基(1→2)-[α-L-吡喃鼠李糖基(1→3)]-β-D-吡喃葡萄糖醛酸苷钠(4)、18α-皂皮酸-3-O-β-D-吡喃半乳糖基(1→2)-[α-L-吡喃鼠李糖基(1→3)]-β-D-吡喃葡萄糖醛酸苷(5)。化合物1~5为新化合物,分别命名为木鳖子苷A、B、C、D、E;均能明显抑制白色念珠菌、近平滑念珠菌、热带念珠菌的生长。Five saponins were isolated from the kernels of Momordica cochinchinensis,by macroporous resin,silica gel,ODS column chromatography,and semi preparative HPLC.Based on MS and NMR analysis,combining with alkaline hydrolysis and acid hydrolysis,their structures were identified as:gypsogenin-3-O-{β-D-galactopyranosyl(1→2)-[α-L-rhamnopyranosyl(1→3)]-β-D-glucuropyranonosyl}-28-O-β-D-xylopyranosyl(1→3)-[β-Dxylopyranosyl(1→4)]-α-L-rhamnopyranosyl(1→2)-β-D-fucopyranoside(1),quillaic acid-3-O-{β-D-galactopyranosyl(1→2)-[α-L-rhamnopyranosyl(1→3)]-β-D-glucuropyranonosyl}-28-O-β-D-xylopyranosyl(1→3)-[β-Dxylopyranosyl(1→4)]-α-L-rhamnopyranosyl(1→2)-β-D-fucopyranoside(2),gypsogenin-3-O-β-D-galactopyranosyl(1→2)-[α-L-rhamnopyranosyl(1→3)]-β-D-glucuropyranonoside sodium(3),quillaic acid-3-O-β-D-galactopyranosyl(1→2)-[α-L-rhamnopyranosyl(1→3)]-β-D-glucuropyranonoside sodium(4),18α-quillaic acid-3-O-β-D-galactopyranosyl(1→2)-[α-L-rhamnopyranosyl(1→3)]-β-D-glucuropyranonoside(5).Compounds 1−5 were new compounds,and named as mubezhisides A,B,C,D,E,respectively.They all could obviously inhibited the growth of Candida albicans,C.parapsilosis,and C.tropicalis.

关 键 词：木鳖子 种仁 三萜皂苷 木鳖子苷 抗真菌 念珠菌 

分 类 号：R284[医药卫生—中药学]