基于网络药理学的中药复方“三黄泻心汤”对高脂血症和AS的治疗机制研究  

Exploring the Therapeutic Mechanism of Traditional Chinese Medicine Compound“Sanhuang Xiexin Tang”on Hyperlipidemia and Atherosclerosis Based on Network Pharmacology

作　　者：吴艳娇 周星 Wu Yanjiao;Zhou Xing(Gannan Healthcare Vocational College,Ganzhou,Jiangxi 341000;Changde Vocational Technical College,Changde,Hunan 415000)

机构地区：[1]赣南卫生健康职业学院,江西赣州341000 [2]常德职业技术学院,湖南常德415000

出　　处：《科技与健康》2025年第1期56-60,共5页Technology and Health

摘　　要：探讨中药复方“三黄泻心汤”对高脂血症和动脉粥样硬化(atherosclerosis,AS)的治疗机制。通过中药系统药理学数据库与分析平台(traditional chinese medicine systems pharmacology,TCMSP)平台筛选收集三黄泻心汤中各药主要活性成分,通过数据库Gene Cards筛出疾病靶点,用Cytoscape 3.6.1构建化合物的成分-靶点网络,分析其度(degree)值。通过Cytoscape 3.8.2软件和String数据库做蛋白相互作用网络图,然后通过数据库Web Gestal对基因靶点做GO富集及KEGG富集分析。结果显示,三黄泻心汤的抗AS和高脂血症的成分-靶点-信号通路网络中有成分283种,靶点36个、信号通路168条。度值较高的候选化合物分子如芦荟大黄素(Rhein)等,主要靶点主要有丝氨酸/苏氨酸蛋白激酶1(AKT1)等,涉及信号通路主要包括IL-17信号通路、PI3K-Akt信号通路等。研究发现,三黄泻心汤通过调节IL-17、PI3K-Akt等信号通路,参与高脂血症和AS的发生发展。To explore the therapeutic mechanism of Sanhuang Xiexin Decoction on hyperlipidemia and atherosclerosis(AS).The main active ingredients of Sanhuang Xiexin Tang were screened and collected through the Traditional Chinese Medicine Systems Pharmacology(TCMSP)platform.Disease targets were identified through Gene Cards in the database,and a component target network of the compounds was constructed using Cytoscape 3.6.1 to analyze their degree values.Create a protein interaction network diagram using Cytoscape 3.8.2 software and String database,and then perform GO enrichment and KEGG enrichment analysis on gene targets using Web Gestal database.The results showed that there were 283 components,36 targets,and 168 signaling pathways in the component target signaling pathway network of Sanhuang Xiexin Tang for its anti AS and hyperlipidemia effects.Candidate compound molecules with high degree values,such as aloe emodin(Rhein),mainly target serine/threonine protein kinase 1(AKT1)and involve signaling pathways such as IL-17 signaling pathway and PI3K Akt signaling pathway.Research has found that Sanhuang Xiexin Tang is involved in the occurrence and development of hyperlipidemia and atherosclerosis by regulating signaling pathways such as IL-17 and PI3K Akt.

关 键 词：网络药理学 三黄泻心汤 大黄 黄芩 黄连 

分 类 号：R285[医药卫生—中药学]