经典名方小蓟饮子的关键信息与现代临床应用分析  

Key Information and Modern Clinical Application of Classic Formula Xiaoji Yinzi

作　　者：王报林 梁绿圆 曹佳蕾 陈晨[4] 陈金雨 罗成鑫 魏炳琦 陈凯丽 徐培聪 邓伟 马丙祥[3,4] WANG Baolin;LIANG Lyuyuan;CAO Jialei;CHEN Chen;CHEN Jinyu;LUO Chengxin;WEI Bingqi;CHEN Kaili;XU Peicong;DENG Wei;MA Bingxiang(The First Clinical Medical School of Henan University of Chinese Medicine,Zhengzhou 450046,China;Center for Research and Development of Classic Prescriptions,Henan Liang Jishi Institute of Traditional Chinese Medicine(TCM)Research,Zhengzhou 450000,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450099,China;School of Pediatrics,Henan University of Chinese Medicine,Zhengzhou 450046,China;School of TCM,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学第一临床医学院,郑州450046 [2]河南梁济时中医药科技研究院经典名方研究与开发中心,郑州450000 [3]河南中医药大学第一附属医院,郑州450099 [4]河南中医药大学儿科医学院,郑州450046 [5]河南中医药大学中医学院,郑州450046

出　　处：《中国实验方剂学杂志》2025年第6期189-198,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81973904);河南省中医药科学研究专项(2018ZY2001);河南省科技厅科技攻关项目(182102311173);河南省特色骨干学科中医学学科建设项目(STG-ZYX06-202144)。

摘　　要：小蓟饮子是治疗泌尿系统疾病的经典名方之一,源自宋代严用和所撰《严氏济生方》。该方由生地黄、小蓟、滑石、木通、蒲黄、藕节、淡竹叶、当归、山栀子、甘草10味药组成,有凉血止血、利水通淋的功效。后世医家基本沿用《严氏济生方》的组成和主治,但在流传中对该方的君药出现争议。通过文献计量法对小蓟饮子的古代文献进行挖掘梳理及现代临床的运用分析。小蓟饮子历代有煮散和汤剂2种剂型,以宋代度量衡换算得出现代药物用量及用法,煮散用生地黄165.2 g,小蓟、滑石、通草、炒蒲黄、淡竹叶、藕节、酒当归、炒栀子仁、炒甘草各20.65 g,上10味锉末,控制粒径在4~10目,每次用药末16.52 g,加入水450 mL煎至240 mL,去药渣趁热空腹送下,建议日3次,换算单次剂量则为生地黄约7.77 g,余药各约0.97 g;小蓟饮子入汤剂则各药20.65 g。其中需进行炮制的有炒蒲黄、酒当归、炒栀子仁、炒甘草,余药生用。小蓟饮子主治下焦结热血淋,为治疗血尿、血淋之专方,其病机为“下焦郁热,损伤膀胱血络,气化失司”。小蓟饮子现代临床中应用在泌尿系统疾病较多,可称为专科专方,但也可根据方证病机扩展到其他系统疾病,如心血管系统疾病。该文全面考证小蓟饮子关键信息以期为其二次研发提供参考。Xiaoji Yinzi is one of the classic prescriptions for treating urinary diseases,originated from the Yan's Prescriptions to Aid the Living(Yan Shi Ji Sheng Fang)written by YAN Yonghe in the Song dynasty.Xiaoji Yinzi is composed of Rehmanniae Radix,Cirsii Herba,Talcum,Akebiae Caulis,Typhae Pollen,Nelumbinis Rhizomatis Nodus,Lophatheri Herba,Angelicae Sinensis Radix,Gardeniae Fructus,and Glycyrrhizae Radix et Rhizoma and has the effects of cooling blood and stopping bleeding,draining water and relieving stranguria.The medical experts of later generations have inherited the original prescription recorded in the Yan's Prescriptions to Aid the Living,while dispute has emerged during the inheritance of this prescription.In this study,the method of bibliometrics was employed to review and analyze the ancient documents and modern clinical studies involving Xiaoji Yinzi.The results showed that Xiaoji Yinzi has two dosage forms:powder and decoction.According to the measurement system in the Song Dynasty,the modern doses of hers in Xiaoji Yinzi were transformed.In the prepration of Xiaoji Yinzi powder,149.2 g of Rehmanniae Radix and 20.65 g each of Cirsii Herba,Talcum,Akebiae Caulis,stirfried Typhae Pollen,Nelumbinis Rhizomatis Nodus,Lophatheri Herba,wine-processed Angelicae Sinensis Radix,stir-fried Gardeniae Fructus,and stir-fried Glycyrrhizae Radix et Rhizoma are grounded into fine powder with the particle size of 4-10 meshes and a decocted with 450 mL water to reach a volume of 240 mL.After removal of the residue,the decoction was taken warm before meals,3 times a day(i.e.,7.77 g Rehmanniae Radix and 0.97 g each of the other herbs each time).In the preparation of Xiaoji Yinzi decoction,20.65 g each of the above 10 herbs are used,with stir-fried Typhae Pollen,wine-processed Angelica Sinensis Radix,stir-fired Gardeniae Fructus,stir-fired Glycyrrhizae Radix et Rhizoma,and raw materials of other herbs.Xiaoji Yinzi is specialized in treating hematuresis and blood stranguria due to heat accumulation in lower energizer,which cau

关 键 词：小蓟饮子 经典名方 古今应用 关键信息 

分 类 号：G254[文化科学—图书馆学] R289[医药卫生—方剂学] R287[医药卫生—中药学]