姜黄连的炮制历史沿革及现代研究进展  

Processing History and Modern Research of Jianghuanglian:A Review

作　　者：李颖 王云[1] 贾哲[1] 严林 金敏 张村 LI Ying;WANG Yun;JIA Zhe;YAN Lin;JIN Min;ZHANG Cun(Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]中国中医科学院广安门医院,北京100053

出　　处：《中国实验方剂学杂志》2025年第6期275-282,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局中药炮制技术传承创新项目(GYZ-KJS-2022-055);国家中医药管理局中医药科学技术研究专项(GZYKJS-2022-004);国家中医药管理局中药炮制技术传承基地项目(国中医药科技中药[2022]59号)。

摘　　要：姜黄连为黄连“以热制寒”的代表性炮制品之一,以生姜制约黄连之苦寒,可追溯至《博济方》,适用于湿热中阻,寒热互结等证。姜黄连既保留了黄连的生物碱类、苯丙素类、黄酮类成分,又引入了生姜中6-姜酚等姜辣素类成分,具有抗炎、抗菌、抗肿瘤、改善胃肠机能等药理活性。2020年版《中华人民共和国药典》和多个地方炮制规范对姜黄连的传统炮制工艺和质量标准都有收载,但具体的工艺参数及质量标准还不完整,限制了该炮制品的生产及临床应用。通过整理归纳近20年姜黄连的炮制历史、工艺研究、质量评价、黄连姜制前后药效药性变化及应用等研究报道,笔者发现,姜黄连在各省市炮制规范收载的炮制方法及标准存在差异,主要体现在姜汁的制备方法、用量、炮制过程及终点的量化标准;此外,选用生姜或干姜制备的姜黄连主要成分及药效和药性也存在一定差异。姜黄连炮制工艺的研究对其质量标准的提高发挥重要作用,该综述可为完善姜黄连的质量评价体系提供参考。Jianghuanglian is one of the representative processed products of Coptidis Rhizoma for treating cold syndrome with drugs of heat nature,and ginger is used to restrict the bitter cold of Coptidis Rhizoma,which can be traced back to Bojifang,and it is suitable for stagnation of damp-heat in middle-jiao,cold-heat mutual knots and other symptoms.Jianghuanglian retains the alkaloids,phenylpropanoids and flavonoids of Coptidis Rhizoma,and also introduces gingerol components such as 6-gingerol in ginger,which has pharmacological activities such as anti-inflammatory,antibacterial,anti-tumor,and improving gastrointestinal function.The 2020 edition of Chinese Pharmacopoeia and many local processing specifications have included the traditional processing process and quality standards of Jianghuanglian,but the specific process parameters and quality standards are incomplete,which limits the production and clinical application of this processed product.By summarizing the processing history,process research,quality evaluation,pharmacodynamic and medicinal property changes and application of Jianghuanglian in the past 20 years,there are differences in the processing methods and standards in various provinces and cities,which are mainly reflected in the preparation method,dosage,processing process and quantitative standards of ginger juice.In addition,there are also certain differences in the changes of the main components of Jianghuanglian prepared from ginger or dried ginger,as well as their efficacy and medicinal properties.The research on the processing process of Jianghuanglian plays an important role in improving its quality standards,and this review can provide a reference for improving the quality evaluation system of Jianghuanglian.

关 键 词：姜黄连 以热制寒 炮制工艺 化学成分 质量评价 药效药性 药理作用 

分 类 号：R22[医药卫生—中医基础理论] R28[医药卫生—中医学] R943.1[文化科学—情报学] G353.11