寿胎丸治疗复发性流产的作用机制研究进展  

Mechanism of Shoutaiwan in Treatment of Recurrent Spontaneous Abortion:A Review

作　　者：党雪 刘飞祥 封俨宸 车志英[1] DANG Xue;LIU Feixiang;FENG Yanchen;CHE Zhiying(Henan University of Chinese Medicine Traditional Chinese Medicine(Zhong jing)School,Zhengzhou 450000,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学中医学院(仲景学院),郑州450000 [2]河南中医药大学第一附属医院,郑州450000

出　　处：《中国实验方剂学杂志》2025年第6期283-291,共9页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(82104730);河南省重点研发专项(231111310300)。

摘　　要：复发性流产(RSA)是妊娠期常见的妇科疾病,临床特征主要表现为反复自然流产,其病理机制复杂尚未完全阐明。中医药将其病机归于冲任虚损,胎元不固,在治疗RSA方面积累了丰富的经验,其中,寿胎丸被广泛用于治疗肾虚引起的滑胎、妊娠期出血和胎动不安等流产症状。近年来,围绕寿胎丸在RSA治疗中的应用及相关实验研究逐渐增多,研究表明寿胎丸主要通过调整妊娠期激素的平衡,缓解妊娠期免疫炎症,改善孕期血凝平衡等过程发挥保胎作用。并通过调节核转录因子E2调节因子2(Nrf2)/血红素氧合酶-1(HO-1)、JAK激酶1(JAK1)/信号转导与转录激活蛋白3(STAT3)和丝裂原活化蛋白激酶(MAPK)等关键信号通路,改善细胞的抗氧化能力,调整滋养层与蜕膜细胞表型,抑制免疫排斥提高妊娠成功率,这些发现不仅揭示了寿胎丸治疗RSA的多重生物学基础,也为其临床应用和进一步的机制研究提供了科学依据,然而目前对寿胎丸治疗RSA的系统综述仍然缺乏。因此,该综述通过对现有的研究成果进行归纳、总结,系统性地分析已有的文献和研究,深入探讨寿胎丸调控RSA的主要药理作用和有关信号通路,以期为寿胎丸治疗RSA的临床应用及未来的实验研究提供重要参考依据。Recurrent spontaneous abortion(RSA)is a common gynecological disease during pregnancy,clinically characterized by repeated spontaneous abortions,yet its pathological mechanism remains incompletely understood.Traditional Chinese medicine attributes the pathogenesis of RSA to the deficiency of Chong Ren and the lack of fetal solidity.It has amassed experience in treating RSA,with Shoutaiwan being widely utilized for addressing miscarriage symptoms such as habitual abortion due to kidney deficiency,bleeding during pregnancy,and fetal movement.In recent years,there has been a gradual increase in experimental studies on the application of Shoutaiwan in treating RSA and on related experiments.These studies have demonstrated that Shoutaiwan preserves the fetus mainly by modulating hormone balance,alleviating immune inflammation,and enhancing blood coagulation equilibrium during pregnancy.Besides,through the modulation of key signaling pathways such as nuclear factor,erythroid 2 like 2(Nrf2)/heme oxygenase-1(HO-1)and Janus kinase 1(JAK1)/signal transducer and activator of transcription(STAT),as well as mitogen-activated protein kinase(MAPK),Shoutaiwan has improved cellular antioxidant capacity,adjusted the phenotype of trophoblast and metaphase cells,and inhibited immune rejection,thus improving the pregnancy success rate.These findings not only elucidate the diverse biological foundations underlying Shoutaiwan's efficacy in treating RSA but also offer a scientific rationale for its clinical application and further mechanism research.Nonetheless,there remains a dearth of systematic reviews on RSA treatment with Shoutaiwan.Therefore,this review summarizes and synthesizes existing research findings to systematically analyze existing literature and studies,delving deeply into the principal pharmacological effects and associated signaling pathways of Shoutaiwan in regulating RSA.It aims to establish crucial reference points for its clinical application in RSA treatment and future experiments and research.

关 键 词：寿胎丸 复发性流产 药理作用 信号通路 临床应用 

分 类 号：R242[医药卫生—中医临床基础] R287[医药卫生—中医学] R285.5