巨噬细胞激活与极化在糖尿病及其相关并发症的作用及中医药干预  

Role of Macrophage Activation and Polarization in Diabetes Mellitus and Its Related Complications and Traditional Chinese Medicine Intervention

作　　者：陈志超 林巧妮 孙立亚 王金曦 付子珊 杨宇峰[1] 石岩[1] CHEN Zhichao;LIN Qiaoni;SUN Liya;WANG Jinxi;FU Zishan;YANG Yufeng;SHI Yan(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)

机构地区：[1]辽宁中医药大学,沈阳110847

出　　处：《中国实验方剂学杂志》2025年第6期311-320,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家中医药管理局青年岐黄学者项目(国中医药人教函[2022]256号);辽宁省科技厅-辽宁省糖尿病中医病证结合重点实验室项目(2019JH6/10100009);辽宁省教育厅校际合作项目(2100221206);2023年辽宁省教育厅高校基本科研项目(JYTZD2023197)。

摘　　要：糖尿病(DM)的发生与胰岛素抵抗和胰岛β细胞功能障碍关系密切,现代研究发现,巨噬细胞广泛存在于肝脏、脂肪、骨骼肌及胰岛等各类组织器官当中。巨噬细胞M1/M2型极化在DM及其相关并发症的发生发展中具有重要作用,其通过干预炎症反应、改善胰岛素抵抗、促进组织修复等方面发挥重要作用。调控巨噬细胞激活与极化的中药多为益气养阴、清热解毒类药物,这与DM及其相关并发症的中医病因病机相一致。故通过总结各类组织中巨噬细胞激活与极化和胰岛素抵抗之间的机制,阐述中药及其有效成分和中药复方通过多途径调控巨噬细胞极化和调节M1/M2型比例改善DM及其相关并发症研究进展,为日后中医药治疗DM及其相关并发症提供借鉴。The occurrence of diabetes mellitus(DM)is closely related to insulin resistance and islet β cell dysfunction.Modern studies have found that macrophages are widely present in the liver,fat,skeletal muscle,islets,and other tissues and organs.Macrophage M1/M2 polarization plays an important role in the occurrence and development of diabetes mellitus and its related complications by intervening in inflammatory response,improving insulin resistance,and promoting tissue repair.Most of the traditional Chinese medicines that regulate the activation and polarization of macrophages are Qi-replenishing and Yinnourishing,heat-clearing,and detoxicating medicinal,which are consistent with the etiology and pathogenesis of diabetes and its related complications.Therefore,by summarizing the mechanisms between macrophage activation,polarization,and insulin resistance in various tissues,this paper reviewed traditional Chinese medicine and its effective components and compounds in improving diabetes mellitus and its related complications through multi-channel regulation of macrophage polarization and regulation of M1/M2 ratio,providing references for the future treatment of DM and its related complications with traditional Chinese medicine.

关 键 词：巨噬细胞 糖尿病 中医药 胰岛素抵抗 

分 类 号：R259[医药卫生—中西医结合] R587[医药卫生—中医内科学] R781.64[医药卫生—中医学]