基于“内热致癥”探讨铁死亡在糖尿病肾脏病中的作用机制  

Discussion on the Mechanism of Ferroptosis in Diabetic Kidney Disease Based on the Theory of“Internal Heat Induced Disease”

作　　者：陈荟溪 王耀献[2,4] 郑慧娟 刘伟敬[1,2] 侠晨辉 张佳乐 吕杰 孙卫卫[1,2] CHEN Huixi;WANG Yaoxian;ZHENG Huijuan;LIU Weijing;XIA Chenhui;ZHANG Jiale;LYU Jie;SUN Weiwei(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Institute of Nephrology,Beijing University of Chinese Medicine,Beijing 100700,China;Beijing University of Chinese Medicine,Beijing 100029,China;Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学肾病研究所,北京100700 [3]北京中医药大学,北京100029 [4]河南中医药大学,河南郑州450046

出　　处：《中国中医药信息杂志》2025年第3期24-28,共5页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金联合基金(U22A20237);国家自然科学基金面上项目(82174356);中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者-国家中医药领军人才支持计划(2018年)。

摘　　要：糖尿病肾脏病是严重的糖尿病并发症之一,铁死亡引起的病理损伤参与糖尿病肾脏病进展,如何抑制铁死亡进而延缓糖尿病肾脏病是目前学术热点。笔者团队在糖尿病肾脏病“阴虚燥热”理论基础上进一步丰富并提出“内热致癥”的核心病机理论,阐释糖尿病肾脏病的一般发展规律。本文以糖尿病肾脏病“内热致癥”理论中“内热”“癥瘕”为切入点,探讨铁死亡主要病理损伤如激活炎症反应、增强氧化应激、促进纤维化等与“内热致癥”理论的内在机制联系,阐释糖尿病肾脏病“内热致癥”的科学内涵,以期为中医药防治糖尿病肾脏病提供理论参考。Diabetic kidney disease(DKD)is one of the serious complications of diabetes.Ferroptosis causes pathological damage and is involved in the progression of DKD.How to inhibit ferroptosis and delay DKD is a new academic hotspot.The author’s team further enriched and proposed the core pathogenesis theory of“internal heat induced disease”on the basis of the traditional DKD“yin deficiency and dryness-heat”theory,and explained the general development law of DKD.In this article,“internal heat”and“Zhengjia”in the theory of DKD“internal heat induced diseases”are used as the starting point to explore the relationship of the main pathological damage of ferroptosis such as activating inflammatory response,enhancing oxidative stress,promoting fibrosis and so on with the internal mechanism of the theory of“internal heat induced diseases”,further explained the scientific connotation of DKD“internal heat induced diseases”,in order to provide ideas and theoretical basis for the TCM prevention and treatment of DKD.

关 键 词：糖尿病肾脏病 内热致癥 铁死亡 炎症 纤维化 

分 类 号：R259.872[医药卫生—中西医结合]