中药靶向干预PI3K/Akt通路治疗纤维化机制研究进展  

Research Progress in the Mechanism of Targeted Intervention of Chinese Materia Medica in PI3K/Akt Pathway for the Treatment of Fibrosis

作　　者：韩蕾 林姗姗 王帅[1] 毕颖斐[1] 王贤良[1] 毛静远[1] HAN Lei;LIN Shanshan;WANG Shuai;BI Yingfei;WANG Xianliang;MAO Jingyuan(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China)

机构地区：[1]天津中医药大学第一附属医院,国家中医针灸临床医学研究中心,天津300381 [2]天津中医药大学,天津301617

出　　处：《中国中医药信息杂志》2025年第3期180-185,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82274437);国家中医药管理局中医药创新团队及人才支持计划(ZYYCXTD-C-202203)。

摘　　要：器官纤维化是多病因导致的组织慢性损伤,动态持续进展可导致器官结构、功能异常。近年研究表明,中药可通过调控PI3K/Akt通路抑制器官纤维化,对制定抗纤维化策略具有潜在意义。本文梳理PI3K/Akt信号通路在纤维化病程中的作用,并总结可靶向干预PI3K/Akt信号传导的中药单体、药对及复方防治器官纤维化的潜在机制,为中药干预PI3K/Akt通路治疗器官纤维化提供参考。Organ fibrosis is a chronic tissue injury caused by multiple causes,and the continuous dynamic progression will lead to abnormal organ structure and function.Recent studies have shown that Chinese materia medica can inhibit organ fibrosis by regulating the PI3K/Akt pathway,which holds potential significance for developing anti-fibrosis strategies.This article systematically reviewed the role of the PI3K/Akt signaling pathway in the entire process of fibrosis,and summarized the potential mechanisms of Chinese materia medica monomers,drug pairs and compounds that can target and intervene in PI3K/Akt signaling transduction in preventing and treating organ fibrosis,in order to provide reference for the intervention of Chinese materia medica in the PI3K/Akt pathway for the treatment of organ fibrosis.

关 键 词：纤维化 中药 信号通路 药理机制 综述 

分 类 号：R285[医药卫生—中药学]