中药活性成分干预铁死亡治疗糖尿病肾病研究进展  

Research Progress of Active Components of Chinese Materia Medica Intervening Ferroptosis for the Treatment of Diabetic Nephropathy

作　　者：陈欣雨 孟鑫雨 贺驿婷 蔡维维 侯豹 邱丽颖 孙海建 朱雪雪 CHEN Xinyu;MENG Xinyu;HE Yiting;CAI Weiwei;HOU Bao;QIU Liying;SUN Haijian;ZHU Xuexue(Wuxi School of Medicine,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学无锡医学院,江苏无锡214122

出　　处：《中国中医药信息杂志》2025年第3期192-196,F0003,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(82300414);江苏省自然科学基金(BK20231049)。

摘　　要：铁死亡是一种细胞程序性死亡模式,在糖尿病肾病(DN)的发生发展中起重要驱动作用。铁死亡与糖尿病肾固有细胞损伤密切相关,中药可通过调节肾固有细胞铁死亡改善DN,研究应用前景较好。本文综述DN中铁死亡的关键调节因子和调控路径,结合中医理论阐释DN铁死亡“阴阳失衡”,梳理中药活性成分靶向抑制铁死亡的研究现状。中药活性成分调节DN铁死亡具有多靶点、多环节、整体性等特点,可为中药治疗DN机制研究及药物研发提供参考。Ferroptosis is a form of programmed cell death,which plays a crucial driving role in the onset and progression of diabetic nephropathy(DN).Ferroptosis is closely related to the damage of renal intrinsic cells in patients with diabetes.Chinese materia medica can improve DN by regulating the ferroptosis of renal intrinsic cells,with a good research and application prospect.This article reviewed the key regulatory factors and regulatory pathways of ferroptosis in DN,explained the“imbalance between yin and yang”of ferroptosis in DN based on TCM theories,and combed the research status of targeted inhibition of ferroptosis by active components of Chinese materia medica.The regulation of active components of Chinese materia medica on ferroptosis in DN has the characteristics of multiple targets,multiple links and integrity,which can provide a reference for the mechanism research and drug development of Chinese materia medica in treating DN.

关 键 词：中医药 糖尿病肾病 铁死亡 机制 肾保护 综述 

分 类 号：R285[医药卫生—中药学] R259.872[医药卫生—中医学]