分析孟鲁司特钠与丙酸倍氯米松雾化吸入联用对支气管肺炎患儿的临床应用价值  

Clinical Application Value of Montelukast Sodium Combined with Beclomethasone Propionate Nebulization in Children with Bronchopneumonia

作　　者：林春花 LIN Chunhua(Nanping Maternal and Child Health Center,Nanping 353000,China)

机构地区：[1]南平市妇幼保健院,南平353000

出　　处：《世界睡眠医学杂志》2024年第12期2757-2760,共4页World Journal of Sleep Medicine

摘　　要：目的:分析支气管肺炎患儿实施孟鲁司特钠与丙酸倍氯米松雾化吸入联用对其睡眠状况、炎症介质及不良反应的实际影响。方法:选取2019年5月至2024年5月南平市妇幼保健院收治的支气管肺炎患儿130例作为研究对象,按照随机数字表法分对照组和观察组,每组65例。对照组给予丙酸倍氯米松雾化吸入治疗,观察组在对照组基础上联用孟鲁司特钠治疗。采用匹兹堡睡眠质量指数(PSQI)比较2组患儿干预前后睡眠质量的变化,采用阿森斯失眠量表(AIS)比较2组患儿干预前后睡眠障碍的发生情况,比较2组患儿睡眠持续时间,降低闭眼到入眠所需时间,并比较2组患儿的血液炎症指标白细胞计数(WBC)、C反应蛋白(CRP)、降钙素原(PCT)水平变化情况,并比较2组患儿的不良反应总发生率,包括皮疹、腹泻、头痛、皮痒等。结论:应用孟鲁司特钠与丙酸倍氯米松雾化吸入联用治疗支气管肺炎患儿,可以有效延长患儿的睡眠持续时间,降低闭眼到入眠所需时间,有效提升睡眠质量,减低炎症介质与不良反应,值得临床推广应用。Objective:To analyze the actual effects of montelukast sodium combined with beclomethasone propionate nebulization on sleep quality,inflammatory factors,and adverse reactions in children with bronchopneumonia.Methods:A total of 130 children with bronchopneumonia treated at Nanping Maternal and Child Health Hospital from May 2019 to May 2024 were selected as study subjects and randomly divided into a control group and an observation group,with 65 cases in each.The control group received beclomethasone propionate nebulization,while the observation group received montelukast sodium in addition to the treatment in the control group.Sleep quality changes were evaluated using the Pittsburgh Sleep Quality Index(PSQI),and sleep disorders were assessed using the Athens Insomnia Scale(AIS)before and after intervention.Sleep duration,time to fall asleep after closing eyes,blood inflammation indicators such as white blood cell count(WBC),C-reactive protein(CRP),and procalcitonin(PCT),and the total incidence of adverse reactions(rash,diarrhea,headache,itching,etc.)were compared between the two groups.Results:The combination of montelukast sodium and beclomethasone propionate nebulization significantly improved sleep duration,reduced time to fall asleep,enhanced sleep quality,and decreased levels of inflammatory markers(WBC,CRP,PCT).Additionally,the total incidence of adverse reactions was lower in the observation group compared to the control group.Conclusion:The combination of montelukast sodium and beclomethasone propionate nebulization is effective in extending sleep duration,reducing sleep latency,improving sleep quality,and reducing inflammatory factors and adverse reactions in children with bronchopneumonia.This treatment approach is worth promoting in clinical practice.

关 键 词：孟鲁司特钠 丙酸倍氯米松 雾化吸入 支气管肺炎 患儿 睡眠状况 炎症介质 不良反应 

分 类 号：R563.12[医药卫生—呼吸系统] R338.63[医药卫生—内科学]