中药复方及成分改善再生障碍性贫血机制研究进展  

Research Progress on the Mechanism of Improving Aplastic Anemia by Traditional Chinese Medicine Formulas and Ingredients

作　　者：梁钰莹 万宛若 谢滟 秦柳柳[1,2,3] 覃豪丽 郝二伟 杜正彩 邓家刚[2,3,4] 侯小涛 LIANG Yuying;WAN Wanruo;XIE Yan;QIN Liuliu;QIN Haoli;HAO Erwei;DU Zhengcai;DENG Jiagang;HOU Xiaotao(School of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China;Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica,Nanning 530200,China;University Engineering Research Center of Reutilization of Traditional Chinese Medicine Resources,Nanning 530200,China;Guangxi Scientific Experimental Center of Traditional Chinese Medicine,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]广西中医药大学药学院,南宁530200 [2]广西中药药效研究重点实验室,南宁530200 [3]中药资源循环利用广西高校工程研究中心,南宁530200 [4]广西中医药大学广西中医药科学实验中心,南宁530200

出　　处：《世界科学技术-中医药现代化》2025年第1期168-178,共11页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：广西壮族自治区科学技术厅(20-065-38):广西中药药效研究重点实验室运行补助项目,负责人:邓家刚;国家药品监督管理局中药材质量检测与评价(KFKT20322-5):基于传统的进口与地产龙眼肉质量标志物差异性评价,负责人:侯小涛;广西中医药大学校级课题(2022A005):广西中医药大学“桂派中医药传承创新团队”项目,负责人:侯小涛。

摘　　要：再生障碍性贫血是一种罕见的危及生命的骨髓衰竭,其发病率呈上升趋势,且趋于年轻化。中药防治虚劳、血证具有悠久的历史,其治疗再生障碍性贫血涉及多组分、多靶点、多通路的协同调控作用。本文从造血干/祖细胞异常、免疫异常、骨髓微环境异常3个方面分类阐述中药复方及成分对再生障碍性贫血的治疗作用及相关因子表达,并对中药复方中常用药物频次及归经分析,发现补虚药在再生障碍性贫血治疗中使用频次最高,与其以虚为主的病症相符合,并发现与之相关脏器为肝、脾、肾。综述再生障碍性贫血的发生机制及中药对其的预防及治疗作用,对后续有针对性地开展中药改善再生障碍性贫血的研究具有重要意义。Aplastic anemia is a rare and life-threatening bone marrow failure that is becoming more common and tends to affect younger individuals.Traditional Chinese medicine has a long history of preventing and treating asthenia and blood syndrome.Its treatment of aplastic anemia involves coordinated regulation through multiple components,targets,and channels.The article classifies and elaborates on the therapeutic effects of traditional Chinese medicine compounds and their components on aplastic anemia.As well as the expression of related factors from three aspects:hematopoietic stem/progenitor cells,the immune system,and bone marrow microenvironmental abnormalities.It also analyzes the frequency and meridian of commonly used drugs in traditional Chinese medicine compounds.Deficiency tonifying drugs were found to be the most frequently used treatment for aplastic anemia,which is consistent with the deficiency-based nature of the disease.The related organs affected are the liver,spleen,and kidney.This paper reviews the mechanism of aplastic anemia and the preventive and therapeutic effects of traditional Chinese medicine.The study is of great significance for the follow-up research on traditional Chinese medicine in improving aplastic anemia.

关 键 词：造血干/祖细胞异常 免疫异常 骨髓微环境异常 中药复方 中药成分 

分 类 号：R285[医药卫生—中药学] R556.5[医药卫生—中医学]