Materials and devices for high‐density,high‐throughput micro‐electrocorticography arrays  

作　　者：Yang Xie Yanxiu Peng Jinhong Guo Muyang Liu Bozhen Zhang Lan Yin He Ding Xing Sheng 

机构地区：[1]Department of Electronic Engineering,Beijing National Research Center for Information Science and Technology,Institute for Precision Medicine,Laboratory of Flexible Electronics Technology,IDG/McGovern Institute for Brain Research,Tsinghua University,Beijing 100084,China [2]Beijing Engineering Research Center of Mixed Reality and Advanced Display,School of Optics and Photonics,Beijing Institute of Technology,Beijing 100081,China [3]School of Materials Science and Engineering,The Key Laboratory of Advanced Materials of Ministry of Education,State Key Laboratory of New Ceramics and Fine Processing,Laboratory of Flexible Electronics Technology,Tsinghua University,Beijing 100084,China

出　　处：《Fundamental Research》2025年第1期17-28,共12页自然科学基础研究(英文版)

基　　金：supported by the National Natural Science Foundation of China(T2425003,52272277 and T2241026).

摘　　要：The pursuit of precisely recording and localizing neural activities in brain cortical regions drives the development of advanced electrocorticography(ECoG)devices.Remarkable progress has led to the emergence of micro-ECoG(μECoG)devices with sub-millimeter resolutions.This review presents the current research status,development directions,potential innovations and applications of high-density,high-throughputμECoG devices.First,we summarize the challenges associated with accurately recording single or multiple neurons using existingμECoG devices,including passive multielectrode and active transistor arrays.Second,we focus on cutting-edge advancements in passiveμECoG devices by discussing the design principles and fabrication strategies to optimize three key parameters:impedance,mechanical flexibility,and biocompatibility.Furthermore,recent findings highlight the need for further research and development in active transistor arrays,including silicon,metal oxide,and solution-gated transistors.These active transistor arrays have the potential to unlock the capabilities of high-density,high-throughputμECoG devices and overcome the limitations of passive multielectrode arrays.The review explores the potential innovations and applications ofμECoG devices,showcasing their effectiveness for both brain science research and clinical applications.

关 键 词：ELECTROCORTICOGRAPHY Micro-electrocorticography Flexible electronics BIOELECTRONICS Neural electrode array 

分 类 号：R318[医药卫生—生物医学工程]